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New Study Analyzes the Effects of THCV, CBD on Weight Loss

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New research, which was published in the journal Cannabis, shows evidence of the weight loss effects of cannabinoids such as THCV and CBD. The study’s official title is “Weight Loss and Therapeutic Metabolic Effects of Tetrahydrocannabivarin (THCV)-Infused Mucoadhesive Strips,” and studied participants’ use of oral strips to administer a combination of THCV/CBD or a placebo.

The study specifically analyzed metabolic syndrome, which develops when an individual accumulates fat, and causes the body to experience “inflammatory response, insulin resistance, dyslipidemia, hypertension, and fatty liver disease.” The condition can be caused by a variety of factors, most commonly due to chronic inflammation caused by fat deposits or eating too many calories and not exercising enough. Ultimately, metabolic syndrome can lead to more serious conditions such as diabetes, and an increased risk of a stroke or heart attack.

The human body’s endocannabinoid system has previously been confirmed to have positive effects on energy homeostasis (the regulation of energy in the body) and appetite regulation, and researchers set out to analyze how the phytocannabinoids THCV and CBD affect metabolic syndrome.

According to the World Health Organization data from 2022, an estimated 2.5 billion people adults over 18 were considered to be overweight, while 890 million were living with obesity. Older data from the U.S. Centers for Disease Control and Prevention collected between 2017-March 2020 shows that in the United States, 41.9% of adults older than 20 are obese.

This most recent study utilized 31 female and 13 male participants, all with an average age of 51.75 years. Participants were given one of two different doses of THCV/CBD, or a placebo. The lower dose included 8 mg THCV/10 mg CBD, while the higher dose included 16 mg THCV/20 mg CBD, which was taken daily via mucoadhesive oral strips over the course of 90 days.

Researchers shared that there were significant results to report. “Use of the THCV/CBD strip was associated with statistically significant weight loss, decreases in abdominal girth, systolic blood pressure, and total and LDL cholesterol,” researchers explained. “The study was limited by small sample sizes in both the high dose and placebo groups.”

Ultimately, participants who were given both the lower and higher doses of THCV/CBD showed the most improvement. “The 16 mg/20 mg daily dose was superior for weight loss compared to the 8 mg/10 mg daily dose; both sets of results differed from placebo in a way that was statistically significant. The results of this study were congruent with the prior unpublished studies of a hemp extract containing significant percentages of THCV, CBDV, and CBD,” researchers concluded.

THCV is said to have been first discovered by researcher Edward Gill and his team in 1970. At the time, cannabis tinctures were a licensed medicine in the United Kingdom, referred to in the British Pharmaceutical Codex (BPC). Cannabis tinctures were removed from the BPC of 1932, although it remained in the BPC of 1949. One year after Gill discovered the compound, it was studied by Frans Merkus who officially referred to it as THCV.

Although THCV appeared in numerous animal studies over the years, its effects on obesity and its “weight loss” properties came from a study by GW Pharmaceuticals in 2013. Researchers administered various levels of THCV to mice for 30 or 45 days, and then measured food and water intake, weight gain, energy expenditure, and more.  The results didn’t show significant food intake or weight gain, but researchers did note increased energy expenditure. “THCV is a new potential treatment against obesity-associated glucose intolerance with pharmacology different from that of CB1 inverse agonists/antagonists,” researchers concluded.

Additionally, another GW Pharmaceutical study in 2016 showed evidence of THCV decreasing “resting state functional connectivity” and increasing “connectivity in the cognitive control network,” leading researchers to suggest positive effects of THCV for obesity.

Other studies, such as one published in 2020, also found that THCV could be a beneficial treatment for those with obesity and diabetes. “However, the uniquely diverse properties of THCV provide neuroprotection, appetite suppression, glycemic control, and reduced side effects, etc.; therefore, making it a potential priority candidate for the development of clinically useful therapies in the future. Hopefully, THCV could provide an optional platform for the treatment of life-threatening diseases.”

Other studies have shown how THCV can benefit those suffering from Parkinson’s disease, schizophrenia, cancer, pain, inflammation, and untreatable epilepsy.

Most recently in February, cannabis genetics company Phylos announced the results of its THCV study using its “Natural Natural™ THCV” product. Phylos Chief Scientific Officer Alisha Holloway, PhD, explained the significance of their findings in a press release. “This study signifies a pivotal moment for the cannabis industry in understanding the effect of THCV in combination with THC,” Holloway said. “The Natural Natural THCV study allows us to leverage our exceptional plants in the advancement of targeted cannabis products, and to chart new territories in understanding the efficacy of natural cannabinoids.”



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Best CBD for dogs of 2025 by Leafly

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Recommendations on the best CBD for dogs are made by Leafly’s Product Picks team after extensive research, internal debate, and expert consultation. If you buy through links on this page, we may earn a small commission.


Looking to help your pup chill out, manage pain, or ease anxiety during firework season? CBD for dogs has become a go-to option for pet parents seeking natural relief without the high. We’ve sniffed out the best CBD products for dogs, from tasty treats to tinctures, to help your furry friend feel their best.


A quick look at the best CBD for dogs

Best overall: Cornbread Hemp Full Spectrum CBD Oil for Pets

Best oil tincture: cbdMD Broad Spectrum CBD Dog Oil Tincture

Best chews: R&R Multifunctional CBD Dog Chews

Best for picky eaters: BATCH Pet CBD Oil Tincture

Best treat format: Dad Grass CBD Dog Bones

Best joint support: Medterra Pet Hemp Joint Support Chews

Best calming support: Honest Paws Calm CBD Bites for Dogs

Best digestive support: Lazarus Naturals CBD Dog Chews, Digestive Health

Best skin and allergy support: Charlotte’s Web Skin & Allergy Chews for Dogs

Best veterinary strength: ElleVet Hemp Oil for Dogs

Best senior dog support: CBD Dog Health Heal: CBD Oil for Dogs


Brand Product Format Flavor CBD Size/Amount Price
Cornbread Hemp Full Spectrum CBD Oil for Pets Oil tincture Corndog 25mg 30 mL $49.99
cbdMD Broad Spectrum CBD Dog Oil Tincture Oil tincture Peanut Butter 10, 25, or 50mg 30 mL $24.99
R&R Multifunctional CBD Dog Chews Chews Chicken 5mg 60 chews $45.00
BATCH Pet CBD Oil Tincture Oil Tincture Bacon, Salmon, or Chicken 12, 25, or 50mg 30 mL $35.00
Dad Grass CBD Dog Bones Chews Pumpkin 4mg 20 bones $25.00
Medterra Pet Hemp Joint Support Chews Chews Peanut Butter 10mg 30 chews $34.99
Honest Paws Calm CBD Bites for Dogs Bites Peanut Butter 5mg 30 bites $28.47
Lazarus Naturals CBD Dog Chews, Digestive Health Chews Pumpkin 10mg 30 chews $17.00
Charlotte’s Web Skin & Allergy Chews for Dogs Chews Chicken 2.5mg 30 or 60 chews $19.99
ElleVet Hemp Oil for Dogs Oil tincture Flavorless 2,100mg hemp extract per bottle 15, 30, or 60 mL $67.15
CBD Dog Health Heal: CBD Oil for Dogs Oil tincture Flavorless 37mg 30 mL $84.99

How to use CBD for dogs

Pet owners turn to CBD products for dogs to help manage a variety of health and behavioral issues. Derived from hemp, cannabidiol (CBD) interacts with the endocannabinoid system—a network found in both humans and animals that helps regulate things like mood, pain, appetite, and immune response.

For dogs, this means CBD may help reduce anxiety during stressful situations like thunderstorms, fireworks, or vet visits, and may also be used to support mobility in aging pups with joint stiffness. Unlike THC, CBD won’t get your dog high, making it a popular option for pet relief when dosed correctly.

Using CBD for your dog typically involves administering a measured amount daily and consistently over time, most commonly through flavored treats, soft chews, or oil tinctures that can be dropped directly into their mouth or mixed into food. Many pet parents report seeing noticeable improvements in their dog’s demeanor, activity level, and overall comfort within a few days to a couple of weeks of beginning a CBD routine.

It’s always a good idea to consult with your veterinarian before starting any new supplement, especially if your dog is on medication or has underlying health conditions. With quality products and responsible use, CBD may be a helpful tool in a holistic approach to your dog’s wellness.

How to select the best CBD for dogs

When shopping for CBD products for your dog, it’s important to look for full- or broad-spectrum hemp extract like the ones on our list, which contain beneficial cannabinoids and terpenes without the THC buzz. Transparency with ingredients and dosing is key—the brands on this list offer third-party lab results (COAs) that confirm potency and screen for pesticides, heavy metals, and other nasties.

We looked for brands with clear dosing guidelines based on your dog’s weight, so you can confidently dial in the right amount for your pet. Some brands focus on organic ingredients and condition-specific formulas, while others offer flavor and potency options to meet your dog’s specific needs.

Whether your pup prefers peanut butter-flavored treats or you need a flavorless oil to add to meals, we sourced options for every taste and temperament. The selections in this list prioritize transparency and effectiveness because your dog deserves the same quality you’d expect for yourself.

Read on to find the best CBD for dogs of 2025.



Best overall: Cornbread Hemp

The best CBD for dogs in an oil tincture format from Cornbread Hemp, pictured here with the bottle, dropper, and packaging

25mg CBD

Cornbread Hemp makes their hemp extract from USDA-organic, Kentucky-grown hemp flower, using only flower, rather than sticks & stems, to create a full-spectrum oil that’s rich in the cannabinoids and terpenes you want for effective support. We highly recommend their line of CBD oils for humans who want the best, most wholesome relief, and the same goes double for their pet formula for your furry friends.

30 mL | Corndog

You’ll find only organic MCT coconut oil, organic hemp flower extract, and vegan corndog flavoring in this formula. Pets that may stick up their noses at the flavors of a planty full-spectrum extract will come running for Cornbread Hemp’s vegan corndog flavoring. And Cornbread’s made dosing easy so you’ll be ready when they do—they recommend one full dropper of 25mg CBD for an 80lb dog, with clear markers on the dropper to reduce the dose by pet-size for a 19mg dose for 60lb dogs, a 13mg dose for 40lb dogs, and so on.


Best CBD oil: cbdMD

New customers get 25% off with code LEAFLY25.

A tincture dropper bottle of our pick for the best CBD for dogs overall from cbdMD

10, 25, or 50mg CBD

cbdMD brings their signature quality to CBD for dogs with their veterinarian-formulated Superior Broad Spectrum CBD Dog Oil. The high-quality hemp extract contains cannabinoids and additional terpenes to offer your dog whole-body benefits to help encourage calmness, relaxation, and mobility. Always third-party lab tested to ensure purity and quality, their formula is also vegan, gluten-free, and THC-free, as you’d expect from a broad-spectrum formula.

30 mL | Peanut Butter

The peanut butter flavor and oil format make this CBD simple to administer, and we love that it comes in three different strengths so you can easily match the right product to your dog’s size and particular needs. The 300mg strength oil for small–medium dogs contains 10mg CBD per 1 mL dropper, while the 1500mg strength oil contains 50mg CBD per 1 mL dropper, with the 750mg strength oil falling in between at 25mg CBD per 1 mL dropper.


Best CBD chews: R&R

Use code LEAFLY20 for 20% off your first purchase at checkout. This offer can be used with multi-product and subscription orders.

A green jar of CBD dog chews from R&R, our pick for the best CBD for dogs in the chews category. Two pyramid stacks for three chews sit on either side of the chews jar.

5mg CBD

These Multifunctional CBD Dog Chews from the hemp experts at R&R deliver 5mg CBD per piece in a tasty chew format that’s easy for your dog to love. Made with chicken liver & protein, sweet potato, flax seed, and high-quality, full-spectrum hemp extract, these chews will feel as familiar as your dog’s favorite treats, with the plant-powered benefits of CBD in every bite.

60 chews | Chicken

R&R recommends one chew for pets 25 lbs or less and two or more chews for pets over 26 lbs. CBD is most effective when taken consistently, so R&R advises it may take 5-7 days of daily dosing for your pet to experience the best results. Once CBD accumulates in the system, your dog may experience relief from pain and stress in as little as five minutes.


Best for picky eaters: BATCH

Use code LEAFLY for 20% off your order. Applies to both one-time purchases and subscriptions. One use per customer. No other restrictions.

A dropper bottle of BATCH Pet CBD Oil Tincture in the Salmon flavor

12mg, 25mg, or 50mg CBD

The review section for BATCH’s Pet CBD Oil Tincture is overflowing with stories and pictures of happy dogs whose owners have seen their daily lives improve while using the brand’s high-quality oil tincture. BATCH’s formulas for humans and pets are crafted in-house from 100% organic, Wisconsin-grown hemp plants, and the care they put into their products is on full display here.

30 mL | Bacon, Salmon, or Chicken

We were especially impressed with the personalization options for pet owners, making it easier to select the right formula for picky pets with specific taste preferences. BATCH’s pet oil comes in bacon, salmon, and chicken flavors, so you can serve up something you know your pooch will love. The oil also comes in three concentrations so you can easily select a CBD potency that works best for your animal’s size.


Best CBD treat: Dad Grass

4mg CBD

A CBD treat that helps cool dogs chill, CBD Dog Bones from Dad Grass contain 4mg CBD per bone for wholesome goodness that keeps tails wagging. Always lab-tested for purity and potency, these CBD Dog Bones are vegan, gluten-free, all-natural, and non-GMO so Fido can feel his best. Crafted with real pumpkin and organic, full-spectrum hemp oil, they’re made so dogs will love the taste and happily receive their daily dose of CBD to help with calming nerves and to encourage overall wellness.

20 bones | Pumpkin

Dad Grass recommends 1mg CBD per 10 lbs, so pet owners can easily scale up with one or more bones or break apart a single bone for littler guys. Leave it to Dad Grass to make a pet product that’s got as much style as substance—you can trust that their organic full-spectrum oil is the good stuff, and the classic bone shape brings major bag appeal for a price that’s right.


Best joint support: Medterra

Use code LEAFLY25 to get 25% off your one-time purchase.

A white and purple bag of Pet Hemp Joint Support Chews from Medterra

10mg CBD

For pet parents hoping to enhance their dog’s joint health and mobility, Medterra’s Pet Hemp Joint Support Chews are specially formulated for just that. 10mg of high-quality hemp extract is combined with joint-supporting ingredients like Glucosamine and MSM to help alleviate discomfort and promote healthy activity. The peanut butter chews allow for simple dosing with natural ingredients and a flavor that dogs will sit, stay, and come for.

30 chews | Peanut Butter

A detailed guide is provided on the back of the packaging, so the recommended dose for your dog is always close at hand. There’s guidance for both “Maintenance” and “Advanced Dosing” broken down by pet size, making it simple to adjust your dog’s daily dose based on their specific needs. With a long-standing reputation for effective CBD products for humans, Medterra makes sure they lend the same level of quality to your pets.


Best calming support: Honest Paws

A blue resealable package of Calm CBD Bites for Dogs from Honest Paws, with peanuts placed around the packaging

5mg CBD

If your dog could use some extra help around fireworks, plane rides, or separation nerves, Honest Paws makes these Calm CBD Bites for Dogs to foster relaxation and support emotional balance. With their US-grown, organic, full-spectrum hemp extract, these bites can provide natural relief in an organic peanut butter flavor that’s popular with pets. If you’re unsure of whether your dog might prefer a treat format or an oil tincture, Honest Paws also bundles their Calm CBD Soft Chews with their Calm CBD Oil in the Peaceful Dog Bundle so you can test out which is a more effective administration method for your pet.

30 chews | Peanut Butter


Best digestive support: Lazarus Naturals

A light-orange, resealable pouch bag of Digestive Health CBD Dog Chews in Pumpkin flavor from Lazarus Naturals

10mg CBD

Lazarus Naturals is a top producer of high-quality CBD products, with an Organic Pet CBD Tincture that comes highly recommended—but their CBD Dog Chews for Digestive Health are a real standout for their targeted approach to digestive support for dogs. In addition to full-spectrum hemp extract, the chews include pumpkin, prebiotics, and probiotics to help your furry friend feel their best.

30 chews | Pumpkin


Best skin and allergy support: Charlotte’s Web

Skin & Allergy Chews for Dogs in a brown and light-purple bag

2.5mg CBD

Skin & Allergy Chews from Charlotte’s Web are formulated to help alleviate discomfort from itchy skin and seasonal allergies for dogs, including ingredients like Nettle Leaf, Marshmallow Root, and Fish Oil Concentrate, along with their full-spectrum, US-grown hemp extract. Pet owners share in reviews that they’ve seen an improvement with reduced scratching and paw-licking in their dogs. Wholesome ingredients and an easy-to-love chicken flavor make this a favorite for owners and pets alike.

30 or 60 chews | Chicken


Best veterinary strength: ElleVet

ElleVet veterinary strength hemp oil for dogs, one of our picks for the best CBD for dogs

2,100mg hemp per bottle (servings vary)

ElleVet Hemp Oil for Dogs offers a clinically backed, complete-spectrum hemp oil designed to support dogs’ mobility, calmness, and overall wellness. 1 mL contains 70mg of hemp extract, including CBD and CBDA, formulated with organic sesame seed oil. ElleVet provides detailed dosing information, with guidance by pet weight, support type, and duration of use, and can be purchased with a syringe-style dropper for exact dosing even for dogs under 10 lbs. This oil is the original ElleVet product and the exact blend used in their clinical trials, so you know your best friend is in the best of hands.

15, 30, or 60 mL | Flavorless (plant matter aroma from hemp extract)


Best senior dog support: CBD Dog Health

A dropper bottle with a light green label featuring a white poodle breed

37mg CBD

CBD Dog Health’s Heal: CBD Oil for Dogs is a full-spectrum hemp extract specially formulated to support senior dogs. Each 1 oz bottle contains 1,100 mg of cannabinoids, including CBD, CBG, and CBN, derived from non-GMO, pesticide-free hemp. This oil is crafted with the issues facing aging pets in mind, targeting pain management, inflammation, and anxiety, as well as promoting better mobility and comfort. Formulated under veterinary guidance for optimal efficacy, consider Heal: CBD Oil for Dogs to help bring some extra brightness to your dog’s sunset years.

30 mL | Flavorless


Why you can trust Leafly Product Picks

Leafly is the world’s leading cannabis discovery platform and provides a vast library of content from some of the most respected voices in cannabis. Leafly Product Picks prioritizes accuracy and integrity in our selections, working through mountains of research and testimonials to source products you can trust.


Anna Elliott: Senior Content Editor, Brands & Products

portrait photo of woman with short dark hair and glasses in a black polo shirt against an aqua-green background

Anna Elliott is Leafly’s Senior Content Editor, Brands & Products. She’s been with Leafly since 2021, managing and editing brand-related content and bringing the best stories on the industry’s top products to life. With a decade of experience reviewing products, covering brands, and editing stories, Anna loves talking up the people & products that make a real difference in readers’ every day. She’s found that Space Mints makes the perfect pairing for enjoying her frankly irresponsible vinyl collection.




For business inquiries, please direct messages to affiliate@leafly.com.




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Avicanna caps record year of sales as it swims out of the red

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Avicanna Inc. (TSX: AVCN) (OTCQX: AVCNF) posted fourth quarter revenue of $6.6 million for the period ending Dec. 31, 2024, wrapping up a year of some stability in the Canadian biopharmaceutical company’s commercial ventures.

The Toronto-based cannabinoid-focused firm achieved $25.5 million in annual revenue, a 52% rise from 2023. Still, it posted a fourth-quarter net loss of $440,094, a significant improvement versus the $2.4 million loss reported in the same quarter of 2023, according to filings.

“We are proud to report our most successful year to date, marked by improved financial results and continued advancements in our commercial, R&D and clinical programs,” CEO Aras Azadian said in a statement. “In 2024, we strengthened our financial foundation, achieved self-sufficiency, and established a solid basis for further growth, international expansion, and innovation.”

The fourth quarter capped a year of consistent quarterly performance, with revenue ranging from $6.1 million to $6.6 million across the four quarters.

Avicanna for the full year saw its gross profits reach $12.9 million, up 94% from 2023, while gross margins improved to 51% from 40% a year earlier. The company still reported an annual net loss, though it narrowed considerably to $4.7 million from $6.6 million in 2023. Adjusted EBITDA loss improved by 68% to $1.4 million, versus a loss of $4.3 million in 2023.

A big portion of Avicanna’s revenue came from its MyMedi.ca platform, which was acquired from Shoppers Drug Mart in 2023. It generated over $21 million in gross revenue during 2024. The platform, operated by Northern Green Canada Inc., functions as a medical cannabis care service providing products, bilingual pharmacist-led patient support and educational resources.

The company’s Canadian operations continued to be the primary revenue driver, ending the year with 42 proprietary commercial SKUs and 136 unique commercial listings, it said. The company sold around 200,685 wholesale units in 2024, an 8% increase from the previous year.

International revenue grew to $1.9 million, a 428% increase from $364,419 in 2023, driven by new licensing and supply agreements.

The company saw several operational achievements during 2024, including the start of a real-world evidence study aimed at enrolling 1,000 patients to “better understand the potential therapeutic use of medical cannabis,” led by the head of The Canadian Pain Society.

The firm also obtained drug registration in Colombia for Trunerox, a proprietary oral formulation with 10% CBD for treating severe seizures related to Lennox-Gastaut Syndrome and Dravet Syndrome. The company plans to commercialize Trunerox in Colombia in 2025, where it expects it to be covered by insurance.

Avicanna throughout the year repaid an outstanding principal balance of $1.3 million on its non-convertible debentures issued in August 2023 and raised additional capital through private placements.

The company ended the year with a cash balance of $448,028, slightly lower than the $477,198 reported at the end of 2023. Last month, the company applied for and was granted a Management Cease Trade Order due to delays in meeting deadlines for certain statutory filings.



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Xebra Brands plans $150K financing for Mexico expansion push

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Xebra Brands Ltd. (CSE:XBRA) (OTCQB:XBRA) is looking to raise $150,000 through a private placement while settling $450,000 in debt, the company announced late Tuesday.

The company said it will issue up to 3 million units priced at 5 cents each, with each unit containing one common share and a half-warrant exercisable at 10 cents for two years.

The debt settlement involves issuing up to 9 million shares to company insiders and service providers at the same 5-cent valuation.

Last year, Xebra said it completed its first manufacturing run of Elements CBD products through Restorative Botanicals, aiming to import them into Mexico through its subsidiary once permits are granted. The company previously secured a distribution deal with ICAN Pharmacies FADERMEX to sell the products across seven pharmacy locations. The company previously secured a unanimous Mexican Supreme Court decision supporting its cannabis operations there in 2021.

“By focusing on strategic partnerships and accretive M&A in both the U.S. and Mexico, along with our robust commercial activities, we are well-positioned to capitalize on the significant opportunities in the CBD market in Mexico ahead of legalization,” Rodrigo Gallardo, interim CEO of Xebra Brands, said in a news release last summer. “Our dedicated team is working tirelessly to ensure that Xebra’s Elements brand becomes a household name, delivering exceptional products that meet the highest standards of quality and consumer satisfaction.”

The company, which claims exclusive rights to produce and sell cannabis products (containing less than 1% THC) in Mexico, projects the country’s cannabis market could reach $3.2 billion by 2026, with CBD sales accounting for $210 million, according to company market research citing Statista Market Insights data.

Xebra around that same time tapped veteran consumer goods executive Melise Panetta and her consulting firm. Panetta, who held senior roles at PepsiCo and SC Johnson, brings cannabis industry expertise including work with Keef Colas and High Times brands, according to the company.

Company officers and directors are expected to participate in both deals, which require Canadian regulatory approval. Xebra indicated it would use proceeds for working capital and general corporate purposes. The company aims to close both deals by Jan. 30.



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