Only with a card. Mississippi permits medical cannabis for registered patients and prohibits recreational sales and possession entirely.
The path here was unusual. Mississippi voters approved a medical marijuana initiative, Initiative 65, in November 2020. The Mississippi Supreme Court invalidated it in May 2021 because of the state’s ballot-initiative signature requirements. The Legislature then enacted the Mississippi Medical Cannabis Act in 2022, which created the program that operates today under the Mississippi Department of Health.
The Cannabis Patient Registry System serves as the central database tracking registered patients, caregivers, and licensed businesses.
Qualifying conditions
Mississippi law recognizes a defined list of qualifying conditions:
Terminal and degenerative diseases
- Cancer
- ALS (amyotrophic lateral sclerosis)
- Parkinson’s disease
- Huntington’s disease
- Muscular dystrophy
- Alzheimer’s disease and agitation of dementia
Chronic conditions
- Chronic pain refractory to appropriate opioid management
- Diabetic or peripheral neuropathy
- Spinal cord disease or severe injury
- HIV/AIDS
- Hepatitis
- PTSD
- Crohn’s disease and ulcerative colitis
- Sickle-cell anemia
Specific symptoms and conditions
- Glaucoma
- Cachexia or wasting syndrome
- Severe or intractable nausea
- Seizures, including epilepsy
- Severe and persistent muscle spasms, including multiple sclerosis
- Spastic quadriplegia
- Autism
The law also covers any chronic, terminal, or debilitating condition producing the symptoms listed above, giving practitioners some latitude in certification decisions.