It has become a wellness focus, but how does marijuana and alcohol impact gut health?
Its awareness has significantly increased in the last decad, becoming a popular topic in both scientific research and public consciousness. While the concept of the gut-brain axis and the importance of the gut microbiome has been studied for decades, it is only recently that the general public has become more aware of the impact of gut health on overall well-being. Here is how alcohol and cannabis affect gut health.
More people are questioning how lifestyle choices—especially substance use—impact the digestive system. While alcohol and cannabis are commonly used for social and recreational purposes, they interact with the gut in strikingly different ways. Understanding these differences can help guide healthier decisions, particularly for those prioritizing wellness and long-term health.
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Alcohol consumption, particularly in excess, has long been associated with poor gut health. Alcohol can damage the lining of the gastrointestinal tract, increase intestinal permeability (commonly known as “leaky gut”), and disturb the balance of the microbiome—the trillions of bacteria help regulate digestion, immune function, and even mood.
Heavy drinking promotes the overgrowth of harmful bacteria and reduces beneficial strains like Lactobacillus and Bifidobacterium. This imbalance can trigger inflammation, digestive discomfort, and weaken the gut’s natural defenses. Chronic alcohol use has also been linked to gastrointestinal diseases such as gastritis, ulcers, and inflammatory bowel disease (IBD).
Cannabis interacts with the gut through the endocannabinoid system (ECS), a network of receptors help regulate digestion, appetite, and immune response. Unlike alcohol, cannabis does not damage the gut lining or directly alter gut permeability in most users. In fact, some studies suggest cannabinoids like CBD and THC may have anti-inflammatory effects which could benefit conditions such as Crohn’s disease or irritable bowel syndrome (IBS).
Cannabis may also indirectly support gut health by reducing stress and anxiety—two factors known to worsen digestive symptoms. However, research is still emerging. Some users report slowed digestion or appetite changes with cannabis use, and smoking cannabis can carry respiratory and cardiovascular risks that don’t directly relate to the gut but may affect overall health.
Both alcohol and cannabis can have different effects depending on dose, frequency, and form of consumption. Occasional moderate drinking may have limited gut impact for some individuals, while daily heavy use is clearly harmful. Similarly, cannabis edibles may influence digestion differently than smoking or vaping, and high-THC products can have stronger psychoactive effects.
When it comes to gut health, alcohol tends to be a clear disruptor, while cannabis presents a more nuanced profile. While early research shows potential benefits of cannabinoids for gut inflammation and stress-related digestive issues, more clinical studies are needed.
For individuals concerned with maintaining a healthy microbiome and digestive system, moderation and informed choices remain key.
The kids are foul mouth, opinionated, and always on point…and they love a little green plant
Since its debut in 1997, South Park has never shied away from taboo topics, and marijuana has been one of its most enduring themes. From early jokes about stoners to full-blown cannabis entrepreneurship, the evolution of weed in South Park mirrors shifting cultural attitudes—and reflects the creators’ own evolving stance.
The show’s co-creators, Trey Parker and Matt Stone, are no strangers to controversy. But when it comes to cannabis, they’ve played both sides of the joint: poking fun at stoner culture while also embracing marijuana legalization as a symbol of personal freedom.
In the early seasons, cannabis was mostly a background gag. Randy Marsh, Stan’s dad, occasionally referenced drug use, but weed wasn’t a focal point. That changed dramatically in Season 23 with the introduction of Tegridy Farms—a fictional marijuana business Randy starts to recapture his lost sense of integrity (“tegridy”).
The Tegridy Farms storyline, which spans multiple seasons, is satire at its best: equal parts critique of corporate cannabis, commentary on the commodification of wellness, and a portrait of midlife crisis. As Randy evolves into a weed mogul, South Park explores everything from THC-infused products to international cannabis trade.
For Parker and Stone, Tegridy Farms is more than a plot device—it’s a reflection of how far cannabis has come in mainstream America. In interviews, both creators have acknowledged they support legalization and view the war on drugs as a failure. “We always thought it was ridiculous,” Stone said in a 2020 interview. “People getting locked up for something safer than alcohol? It never made sense.”
The irony, of course, is that South Park itself has grown up with its audience. Millennials who watched the show in middle school are now adults—many with mortgages, careers, and legal weed in their states. The cannabis storylines, once rebellious, now resonate as social satire for a generation navigating late-stage capitalism and ever-shifting norms.
South Park’s weed content also plays well with search engines. From “Tegridy Farms” memes to fan theories about Randy’s descent into madness, marijuana-themed episodes drive traffic and engagement. It’s smart business—and smart commentary.
Whether it’s lampooning hemp marketing or making fun of anti-pot hysteria, South Park keeps it blunt: weed is part of the culture now. And if there’s one thing Parker and Stone have always understood, it’s how to make culture laugh at itself.
Just days after the Senate confirmed Terrance Cole as the new head of the Drug Enforcement Administration, DEA Administrative Law Judge John Mulrooney — the judge who was tasked with overseeing the stalled-out cannabis rescheduling process — told witnesses in the case that he is retiring “from the bench” on August 1, Marijuana Moment reports.
Judge Mulrooney said his departure “will leave the DEA with no Administrative Law Judge to hear this matter or any of the Agency’s other pending administrative enforcement cases.”
“The Controlled Substances Act requires that DEA administrative enforcement hearing proceedings must be conducted in accordance with the Administrative Procedure Act and presided over by an Administrative Law Judge. 21 U.S.C. § 824(c)(4); 5 U.S.C. § 556(b)(3). Until there is a change in this circumstance, all matters filed in this case will be forwarded to the DEA Administrator, for whatever action, if any, he deems appropriate.” — Mulrooney, in the report
Mulrooney noted that his previously issued orders “remain in full force and effect unless otherwise modified by a successor Administrative Law Judge, the DEA Administrator, or the Attorney General.”
Cole has not yet indicated whether he wants to allow the federal rescheduling process to move forward, although he said previously that the decision would be “one of my first priorities.”
The rescheduling process has been on pause since Mulrooney canceled a hearing in January for expert testimony in the case. The judge said previously that he would not reschedule the case until the agency’s new administrator had been installed.
“Naturally, I wish all the parties the best in resolving this important issue in a fair, transparent, and accurate manner, and extend my heartfelt gratitude to the parties and their representatives for their sincere, diligent, and indefatigable advocacy,” Mulrooney said.
The Department of Health and Human Services first issued the recommendation to move cannabis from Schedule I to Schedule III under federal law about two years ago, under the Biden Administration. Meanwhile, President Trump said last year on the campaign trail that he supported the move to reschedule, but in the six months since the start of his second term, the president has so far failed to take action or even comment on the issue.
The National Cannabis Industry Association, one of the parties advocating for rescheduling in the administrative law case, congratulated Cole on his confirmation to in an open letter this week, urging him to “fulfill President Trump’s campaign promise to ‘unlock the medical uses of marijuana to a Schedule III drug’ and ultimately ‘implement smart regulations, while providing access for adults, to safe, tested product.’”