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CBD Has Potential To Treat Alcohol Use Disorder By Reducing Withdrawal Symptoms And Lowering Relapse Risk, Federally Funded Study Finds

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4 weeks agoon

CBD appears to reduce symptoms of alcohol withdrawal and risk of relapse, while also providing neuroprotective effects, according to a new federally funded study published in the journal Nature.
Researchers at the University of California San Diego set out to investigate how the non-intoxicating cannabinoid might impact people with alcohol use disorder. And the findings of the mice-based study offers additional evidence that CBD could play a role in mitigating the health effects of alcohol use.
A total of 166 rats were included in the research. Two cohorts were intravenously administered doses of synthetic CBD (either 30 or 60 mg/kg), while another set of rodents were used as the control group.
Thirty minutes after the cannabinoid was administered, the researchers ran a series of tests that explored how the drug potentially attenuated the behavioral and neurobiological aspects of alcohol dependence.
They found that CBD was effective to that end by “modulating neuronal excitability and preventing neurodegeneration, supporting its therapeutic potential for AUD and providing mechanistic insights for future research.”
“The present study demonstrates that chronic administration of cannabidiol (CBD) attenuates both behavioral and neurobiological manifestations of alcohol dependence in rodent models,” the study says. “Specifically, CBD reduced alcohol intake and withdrawal symptoms, lowered relapse-like behaviors, normalized neuronal excitability in the basolateral amygdala (BLA), and prevented alcohol-induced neurodegeneration in striatal regions associated with reward and habit formation.”
“Additionally, CBD did not potentiate alcohol’s sedative effects, as shown by no differences in loss of righting reflex duration or locomotor activity during alcohol intoxication, while increasing time spent in the open field’s center, indicating anxiolytic effects. These results underscore CBD’s potential therapeutic utility for alcohol use disorder (AUD) and provide mechanistic insights into its actions.”
The study received funding from the National Institute on Alcohol Abuse and Alcoholism, the University of California San Diego’s Center for Medicinal Cannabis Research and the University of California San Diego’s Preclinical Addiction Research Consortium.
Notably, the study authors said one of the “pivotal” findings of the research is that CBD “reversed alcohol-induced decreases in neuronal excitability in the BLA,” which is “central to alcohol withdrawal and dependence-related behaviors, and its dysregulation contributes to maladaptive processes that drive relapse.”
“In conclusion, chronic CBD administration mitigates key behavioral and neurobiological features of alcohol dependence by reducing withdrawal symptoms, lowering relapse risk, restoring BLA neuronal excitability, and preventing neurodegeneration in striatal regions. Together, these findings highlight CBD’s capacity to preserve functional integrity in neural circuits underlying emotional regulation, reward processing, and habit formation. Further translational research and clinical trials are warranted both to validate CBD’s therapeutic efficacy in human populations and to optimize dosing strategies for individuals with AUD.”
The findings are consistent with a growing body of research that signals CBD and other cannabinoids could help mitigate harms associated with alcohol use.
For example, researchers at the University of Sydney recently published a mice-based study showing that CBD reduces rates of binge drinking and alcohol blood concentrations.
Results of a separate study published in the journal Molecular Psychiatry also indicated that a single, 800-milligram dose of CBD can help manage certain alcohol cravings among people with alcohol use disorder (AUD), supporting the use of the marijuana component as a potential treatment option for problem drinkers.
Federally funded research into the effects of cannabis on alcohol use also found that people who used marijuana immediately before drinking subsequently consumed fewer alcoholic beverages and reported lower cravings for alcohol.
The study follows a separate survey analysis published in March that found that three in four young adults reported substituting cannabis for alcohol at least once per week—a “fast-emerging” trend that reflects the “rapid expansion” of the hemp product marketplace.
The report from Bloomberg Intelligence (BI) found that, across various demographics, cannabis is increasingly being used as an alternative to alcohol and even non-alcoholic beverages as more companies—including major multi-state marijuana operators (MSOs)—expand their offerings.
The findings were largely consist with a growing body of studies indicating that cannabis—whether federally legal hemp or still-prohibited marijuana—is being utilized as a substitute for many Americans amid the reform movement.
An earlier survey from YouGov, for example, found that a majority of Americans believe regular alcohol consumption is more harmful than regular marijuana use. Even so, more adults said they personally prefer drinking alcohol to consuming cannabis despite the health risks.
A separate poll released in January determined that more than half of marijuana consumers say they drink less alcohol, or none at all, after using cannabis.
Yet another survey—which was supported by the National Institute on Drug Abuse (NIDA) and released in December—found that young adults are nearly three times more likely to use marijuana than alcohol on a daily or near-daily basis.
That poll provided more granular, age-specific findings than a similar report published last year, finding that more Americans overall smoke marijuana on a daily basis than drink alcohol every day—and that alcohol drinkers are more likely to say they would benefit from limiting their use than cannabis consumers are.
A separate study published in the journal Addiction last year similarly found that there are more U.S. adults who use marijuana daily than who drink alcohol every day.
In December, BI also published the results of a survey indicating that substitution of cannabis for alcohol is “soaring” as the state-level legalization movement expands and relative perceptions of harm shift. A significant portion of Americans also said in that poll that they substitute marijuana for cigarettes and painkillers.
Another BI analysis from last September projected that the expansion of the marijuana legalization movement will continue to post a “significant threat” to the alcohol industry, citing survey data that suggests more people are using cannabis as a substitute for alcoholic beverages such a beer and wine.
Yet another study on the impact of marijuana consumption on people’s use of other drugs that was released in December suggested that, for many, cannabis may act as a less-dangerous substitute, allowing people to reduce their intake of substances such as alcohol, methamphetamine and opioids like morphine.
A study out of Canada, where marijuana is federally legal, found that legalization was “associated with a decline in beer sales,” suggesting a substitution effect.
The analyses comport with other recent survey data that more broadly looked at American views on marijuana versus alcohol. For example, a Gallup survey found that respondents view cannabis as less harmful than alcohol, tobacco and nicotine vapes—and more adults now smoke cannabis than smoke cigarettes.
A separate survey released by the American Psychiatric Association (APA) and Morning Consult last June also found that Americans consider marijuana to be significantly less dangerous than cigarettes, alcohol and opioids—and they say cannabis is less addictive than each of those substances, as well as technology.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.
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Rhode Island Opens Applications for 24 Adult-Use Dispensary Licenses

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25 minutes agoon
September 15, 2025
[PRESS RELEASE] – WARWICK, R.I., Sept. 12, 2025 – The Cannabis Control Commission (CCC) opened the application period for adult-use cannabis retail licenses, marking the beginning of the largest expansion to Rhode Island’s cannabis industry. The commission is authorized under the Rhode Island Cannabis Act to license up to 24 retail establishments statewide, divided equally across six geographic zones, making this announcement a defining moment in shaping the state’s cannabis marketplace.
“Today’s announcement represents years of work, collaboration and preparation to ensure Rhode Island has a cannabis marketplace that is safe, transparent, and equitable,” CCC Chairperson Kim Ahern said. “The release of this application and launch of our submission portal is not only about opening doors for businesses but about creating meaningful opportunities for Rhode Islanders while keeping public health and public safety at the center of everything we do.”
With only 24 retail licenses available statewide, the launch of the application process is expected to draw significant interest from prospective applicants. Together with the Social Equity Applicant Status Certification Portal, which opened in August, the application process reflects the CCC’s deliberate steps toward building a cannabis industry that prioritizes economic opportunity, equity and fairness in Rhode Island.
“Rhode Island’s cannabis market is poised for growth, and this application is helping us do exactly that,” Gov. Dan McKee said. “As we expand the cannabis industry here in the Ocean State, we’re opening the doors to new investment, new good-paying jobs, and new opportunities for our economy.”
Adult-use retail licenses will authorize sales of cannabis products to adults 21 and older. By releasing the application and opening the submission portal simultaneously, the commission is providing applicants with a transparent process while reinforcing its commitment to accountability and access.
“Today’s release of the adult-use retail license application reflects the commission’s commitment to equity and accountability,” Commissioner Layi Oduyingbo said. “This framework provides applicants with the information they need while reinforcing our responsibility to safeguard public health and consumer safety.”
Commissioner Robert Jacquard said, “The commission aims to make this application process as business-friendly as possible, while upholding standards that will protect public health.”
To ensure the process is fair and accessible, the commission and Cannabis Office will provide technical assistance resources and ongoing guidance for prospective applicants. Applications will be accepted until 4 p.m. on Dec. 29, 2025.
“This is a milestone that reflects the dedication and perseverance of so many people,” Cannabis Office Administrator Michelle Reddish said. “From lawmakers and advocates to community members and our dedicated staff, countless individuals have helped build the foundation for this moment. By publishing the application today, we are taking a historic step toward building a cannabis marketplace that serves consumers, supports equity and advances public health in Rhode Island.”
The adult-use retail license application is available on the commission’s website at www.ccc.ri.gov/auapp.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.
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Can LSD Battle Anxiety? The Answer Is Yes, According to Science

Published
1 hour agoon
September 15, 2025
Hands down, one of the drugs that has received the worst press in the decades marked by the War on Drugs has been LSD. All sorts of things have been said about this molecule: that it drives you crazy, or suicidal, that it remains stored in your body forever, that it irreparably damages the brain… Fortunately, we now have professionals investigating the matter, with a scientific perspective rather than a moralistic or prohibitionist one.
One of the latest findings on the subject seems to directly contradict one of the great myths about LSD: instead of leading to insanity, this compound could reduce anxiety. This is according to a study by Mind Medicine (MindMed) Inc., a biopharmaceutical company that has been researching psychedelic compounds for mental health for many years. While the preliminary results were released in 2022, they were officially published this month in the Journal of the American Medical Association.
This isn’t the first time MindMed has embarked on studying this topic: it had already achieved positive results with LSD for anxiety on another occasion. In fact, the FDA granted Breakthrough Therapy designation for generalized anxiety disorder (GAD) to the company’s proprietary drug candidate, MM120, a pharmacologically optimized formulation of LSD.
LSD and Anxiety: What the MindMed Study Says
The company conducted a multicenter, randomized, double-blind, placebo-controlled Phase 2b study at 22 outpatient psychiatric research centers in the US. The effects of a single dose of MM120 (lysergide D-tartrate, LSD) were analyzed in 198 adults with moderate to severe generalized anxiety disorder (GAD). Participants experienced sustained improvements in their condition over the 12-week observation period.
According to the company’s press release, this is the first randomized, placebo-controlled trial evaluating a single treatment at four dose levels (25, 50, 100, or 200 µg), without any psychotherapeutic intervention.
The optimal dose of MM120 was determined at 100 µg. This demonstrated a “clinically and statistically significant improvement vs. placebo, and a 65% clinical response rate and 48% clinical remission rate” at the end of the experiment.
Likewise, tolerance to the medication was positive, with the expected adverse effects of an LSD experience remaining mild to moderate and lasting only one day.
During the study, participants receiving medication for their condition had to discontinue such treatment under the supervision of the study professionals. Furthermore, on the day of dosing, they were offered “standardized music and eyeshades and could lie down, move freely around the room, read, write, or draw.” It should be noted that the study protocol explicitly prohibited participation in psychotherapy.
Dr. Maurizio Fava, one of the study’s authors, stated that “this study is a true turning point in the field of psychiatry… For the first time, LSD has been studied with modern scientific rigor, and the results are both clinically meaningful and potentially paradigm-shifting for the treatment of GAD. GAD affects 26 million adults in the U.S., yet no new medications have been approved since 2007—and first-line treatments fail 50% of patients.”
Thus, scientific innovation continues to advance against the willful ignorance of prohibitionists, working tirelessly to ensure patients have access to the relief that traditional therapies fail to provide.
This article was first published on El Planteo.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.
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Kentucky Medical Marijuana Dispensaries Should Be Stocked With Products Ready For Sale By Next Month, Top State Official Says

Published
2 hours agoon
September 15, 2025
Kentucky’s top medical marijuana regulator said he expects that dispensary shelves will be stocked with products ready for sale to patients by next month.
Two of the state’s 16 medical cannabis cultivators are now operational, according to Cannon Armstrong, executive director of Kentucky’s Office of Medical Cannabis (OMC).
“If everything goes according to plan for them, I think that they’ll have medical cannabis that will be ready to harvest and be put on the shelf, you know, by October,” he told Spectrum News 1. “So we’re moving and we’re finally getting to a point where we’re, these patients are going to receive this medication sooner than later.”
Armstrong predicted that the first sales will likely occur at a dispensary in Beaver Dam called The Post.
“I think you’re going to see the first products out there based upon just how it’s shaken out,” he said. “You know, someone may step up their timeline and may get out there before that or get product from there and place it somewhere else in the state.”
As of now, OMC has approved more than 19,000 patients certifications, Armstrong said.
He added that medical cannabis supplies should be relatively scarce as the market first launches, and said that as a result initial prices will be higher than they eventually will be.
Earlier this month, Gov. Andy Beshear (D) said he thought medical marijuana would be available to Kentucky patients by the end of 2025.
“The medical marijuana program is moving forward,” he said at a press briefing at the time.
“I think most of our dispensaries now have their home address [and] are set about where they’re going to be, but [for] some of the inspections that have to happen in dispensaries, they have to have product that’s there,” he said. “So I do believe they’ll be operating before the end of the year.”
Those comments came roughly a month after the governor announced that the state’s first medical cannabis dispensary has officially been approved for operations, calling it “another step forward as we work to ensure Kentuckians with serious medical conditions have access to the medicine they need and deserve.
He previously touted an earlier “milestone” in the state’s forthcoming medical marijuana program, with a licensed cultivator producing “the first medical cannabis inventory in Kentucky history.”
Beshear’s office has said that other cannabis licensees, including processors and testing labs, are expected to become operational soon.
In July, Beshear sent a letter to President Donald Trump, urging him to reject congressional spending bill provisions that would prevent the Justice Department from rescheduling marijuana.
In the letter to the president, he emphasized that a pending proposal to move cannabis from Schedule I to Schedule III under the Controlled Substances Act (CSA) is something “you supported in your presidential campaign.”
“That process should be allowed to play out. Americans deserve leadership that won’t move the goalposts on them in the middle of the game,” Beshear said, noting that he was among the tens of thousands who submitted public comments in favor of the reform after it was initiated under the Biden administration, “demonstrating broad public interest in rescheduling.”
“I joined that effort because this is about helping people. Rescheduling would provide suffering patients the relief they need,” the governor said. “It would ensure communities are safer—because legal medical products reduce the illicit market. It would provide new, meaningful research on health benefits.”
Beshear also mentioned a letter to DEA he signed onto last year urging rescheduling, “because the jury is no longer out on marijuana. It has medical benefits.”
Back on the state level, the governor recently said he acknowledges that “it’s taken longer than we would have liked” to stand up the industry since he signed medical marijuana legalization into law in 2023.
In recognition of that delayed implementation, he recently signed an executive order to waive renewal fees for patients who get their cards this year so that they don’t get charged again before retailers open. And another order he signed providing protections for qualified patients who obtain medical marijuana outside of Kentucky “will stay in place.”
Beshear separately announced in May that the state has launched a new online directory that lets people see where medical cannabis dispensaries will be opening near them.
He emphasized that the state has been working to deliver access to patients “at the earliest possible date,” and that involved expediting the licensing process. The governor in January also ceremonially awarded the commonwealth’s first medical marijuana cards.
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Meanwhile, the governor sent a letter to Kentucky’s congressional delegation in January, “urging them to take decisive action to protect the constitutional rights of our law abiding medical cannabis patients” by repealing the federal ban on gun possession by people who use marijuana.
That came after bipartisan Kentucky senators filed legislation that similarly called on the state’s federal representatives to take corrective action, which Beshear said he supports but would like to see even more sweeping change on the federal level.
The federal Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) warned Kentucky residents late last year that, if they choose to participate in the state’s medical marijuana program, they will be prohibited from buying or possessing firearms under federal law.
As far as the implementation of the state’s medical cannabis law goes, Beshear said in his State of the Commonwealth address in January that patients will have access to cannabis sometime “this year.” He also later shared tips for patients to find a doctor and get registered to participate in the cannabis program.
Health practitioners have been able to start assessing patients for recommendations since the beginning of December.
While there currently aren’t any up-and-running dispensaries available to patients, Beshear has further affirmed that an executive order he signed in 2023 will stay in effect in the interim, protecting patients who possess medical cannabis purchased at out-of-state licensed retailers.
During last year’s November election, Kentucky also saw more than 100 cities and counties approve local ordinances to allow medical cannabis businesses in their jurisdictions. The governor said the election results demonstrate that “the jury is no longer out” on the issue that is clearly supported by voters across partisan and geographical lines.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.

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