Jazz Pharmaceuticals plc (Nasdaq: JAZZ) announced it is buying Chimerix (Nasdaq: CMRX) for $8.55 per share in cash, representing a total consideration of approximately $935 million. The price is at a 75% premium and the deal is expected to close in the second quarter of 2025.
Jazz said that the acquisition will create an additional durable revenue opportunity with patent protection into 2037, with the potential to receive a patent term extension. It is paying for the company with existing cash and investments. As of December 31, 2024, the company had cash, cash equivalents and investments of $3 billion
Chimerix’s lead clinical asset is dordaviprone, a novel, first-in-class small molecule treatment in development for H3 K27M-mutant diffuse glioma, a rare, high-grade brain tumor that most commonly affects children and young adults. There are no U.S. Food and Drug Administration (FDA)- approved therapies specifically for H3 K27M-mutant diffuse glioma patients. Currently, radiation is the most common treatment approach.
“Adding dordaviprone to our oncology R&D pipeline will further diversify our portfolio with a medicine that addresses a significant unmet need with no other FDA-approved therapies and limited treatment options for this patient population. If approved, dordaviprone has the potential to rapidly become a standard of care for a rare oncology disease and also contribute durable revenue beginning in the near-term,” said Bruce Cozadd, chairman and chief executive officer, Jazz Pharmaceuticals. “We are encouraged by the dordaviprone clinical trial results to date and look forward to closing the proposed acquisition and working with our new colleagues from Chimerix to fully leverage our combined R&D and commercial expertise to deliver this novel therapy to patients, beginning as early as the second half of this year.”
Drug potential
A New Drug Application (NDA) for accelerated approval of dordaviprone in recurrent H3 K27M-mutant diffuse glioma was recently accepted and granted Priority Review by the FDA. The company told investors that the FDA has set a target Prescription Drug User Fee Act (PDUFA) action date of August 18, 2025. The statement said, “If approved in the U.S., dordaviprone may be eligible for a Rare Pediatric Disease Priority Review Voucher (PRV). Separately, dordaviprone is being studied in the ongoing Phase 3 ACTION trial, evaluating its use in newly diagnosed, non-recurrent H3 K27M-mutant diffuse glioma patients following radiation treatment, potentially extending this treatment option into the front-line setting.”
“We are excited to reach this agreement with Jazz Pharmaceuticals as they bring global scale to broaden our dordaviprone commercial strategy,” said Mike Andriole, President and CEO of Chimerix. “The transaction, if approved, provides the opportunity to advance access to dordaviprone to reach more patients globally. This announcement is the culmination of years of scientific work by our incredibly talented team, and will deliver significant and certain value to our shareholders.”
Diversification
Jazz reported its annual earnings on February 26, 2025, and made it clear it planned to diversify its revenue streams. Jazz reported product sales rose 2% in 2024 to reach $3.8 billion and total revenues were $4 billion. Its cannabis drug for epilepsy, Epidiolex/Epidyolex delivered net sales in 2024 of $972.4 million, which represented 25% of the company’s total net product sales for the year.
The company told investors it has an ongoing Phase 3 trial of Epidyolex for Lennox-Gastaut syndrome, Dravet Syndrome and Tuberous Sclerosis Complex in Japan. In August 2024, the company announced top-line results from the trial. However, the company noted that the trial did not meet the primary efficacy endpoint of a pre-specified percentage change in indication-associated seizure frequency during the treatment period (up to 16 weeks) compared to baseline in Japanese pediatric patients; however, numeric improvements were observed in the primary and several secondary endpoints. Jazz said it is continuing to collect data on Japanese patients and plans to engage with regulatory authorities in Japan regarding a potential new drug application.