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Medical Marijuana ‘Significantly’ Decreases Use Of Opioids By Chronic Pain Patients, New Study Finds

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A new study is offering more evidence that marijuana can serve as an effective substitute for opioids in pain management treatment.

Researchers in Australia at Murdoch University and the Perth Pain Management Centre set out to investigate how the integration of cannabinoids into treatment for people with chronic non-cancer pain would impact opioid use.

The study, published in the journal Pain Management on Monday, determined that “co-prescription of cannabinoids may enable patients to reduce their opioid consumption prescribed for chronic benign pain.”

To assess the relationship between cannabis and opioids in treatment, researchers followed two cohorts of patients over the course of a year: One group of 102 patients at a pain clinic who were already taking opioids and were co-prescribed cannabis and another group of 53 patients at a different clinic who were only receiving opioids, without marijuana.

At the baseline, the median patient was taking about 40 mg of opioids per day. After a year, the group that received a median dose of medical cannabis containing 15 mg delta-9 THC and 15 mg of CBD “significantly” decreased their opioid dose to 2.7 mg per day. The opioid-only cohort after one year was taking a median 42.3 mg per day.

“The introduction of cannabinoids can produce useful reductions in opioid consumption in real-world settings, with additional benefits for disability and insomnia,” the study authors said. “However, this treatment is tolerated by only a subgroup of patients.”

Among the cohort that incorporated cannabis into their treatment regiment, “opioid consumption decreased significantly after both 6 and 12 months.”

“Physical activity and sleep also improved. These findings indicate that medicinal cannabis can help patients to reduce their opioid consumption and improve their physical activity and sleep,” the study concluded.

The findings are also consistent with a growing body of scientific literature exploring the association between cannabis and opioid use.

For example, a study published earlier this year in the journal Drug and Alcohol Review found that, among drug users who experience chronic pain, daily cannabis use was linked to a higher likelihood of quitting the use of opioids—especially among men.

A study published late last year also found that legalizing medical cannabis appeared to significantly reduce monetary payments from opioid manufacturers to doctors who specialize in pain, with authors finding “evidence that this decrease is due to medical marijuana becoming available as a substitute” for prescription painkillers.

Other recent research also showed a decline in fatal opioid overdoses in jurisdictions where marijuana was legalized for adults. That study found a “consistent negative relationship” between legalization and fatal overdoses, with more significant effects in states that legalized cannabis earlier in the opioid crisis. Authors estimated that recreational marijuana legalization “is associated with a decrease of approximately 3.5 deaths per 100,000 individuals.”

“Our findings suggest that broadening recreational marijuana access could help address the opioid epidemic,” that report said. “Previous research largely indicates that marijuana (primarily for medical use) can reduce opioid prescriptions, and we find it may also successfully reduce overdose deaths.”

Another recently published report into prescription opioid use in Utah following the state’s legalization of medical marijuana found that the availability of legal cannabis both reduced opioid use by patients with chronic pain and helped drive down prescription overdose deaths statewide. Overall, results of the study indicated that “cannabis has a substantial role to play in pain management and the reduction of opioid use,” it said.

Yet another study, published in 2023, linked medical marijuana use to lower pain levels and reduced dependence on opioids and other prescription medications. And another, published by the American Medical Association (AMA) last February, found that chronic pain patients who received medical marijuana for longer than a month saw significant reductions in prescribed opioids.

About one in three chronic pain patients reported using cannabis as a treatment option, according to a 2023 AMA-published report. Most of that group said they used cannabis as a substitute for other pain medications, including opioids.

Other research published that year found that letting people buy CBD legally significantly reduced opioid prescription rates, leading to 6.6 percent to 8.1 percent fewer opioid prescriptions.

A 2022 research paper that analyzed Medicaid data on prescription drugs, meanwhile, found that legalizing marijuana for adult use was associated with “significant reductions” in the use of prescription drugs for the treatment of multiple conditions.

A 2023 report linked state-level medical marijuana legalization to reduced opioid payouts to doctors—another datapoint suggesting that patients use cannabis as an alternative to prescription drugs when given legal access.

Researchers in another study, published last year, looked at opioid prescription and mortality rates in Oregon, finding that nearby access to retail marijuana moderately reduced opioid prescriptions, though they observed no corresponding drop in opioid-related deaths.

Other recent research also indicates that cannabis may be an effective substitute for opioids in terms of pain management.

A report published recently in the journal BMJ Open, for instance, compared medical marijuana and opioids for chronic non-cancer pain and found that cannabis “may be similarly effective and result in fewer discontinuations than opioids,” potentially offering comparable relief with a lower likelihood of adverse effects.

Separate research published found that more than half (57 percent) of patients with chronic musculoskeletal pain said cannabis was more effective than other analgesic medications, while 40 percent reported reducing their use of other painkillers since they began using marijuana.

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Newly Posted Texas Medical Marijuana Rules Will Let Doctors Recommend New Qualifying Conditions For Patients

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Texas officials are taking another step toward implementing a law to significantly expand the state’s medical marijuana program—posting a draft of proposed rules to let physicians recommend new qualifying conditions for cannabis and create standards for allowable inhalation devices.

The state Health and Human Services Commission is set to formally file the proposed rules next week, and they’ll subsequently be published in the Texas Register, opening up a 31-day public comment period.

This comes about a week after the the Department of Public Safety (DPS) previewed a separate set of rules to increase the number of licensed dispensaries under recently passed legislation.

To comply with the medical marijuana expansion bill that Gov. Greg Abbott (R) signed into law in June, DPS will be formally proposing a future licensing application process, security standards for satellite locations and license revocation parameters.

Meanwhile, the new memo published ahead of a Health and Human Services Commission Executive Council meeting scheduled for Thursday, August 21 outlines additional steps that are being taken.

Specifically, the department is proposing rules that “explain how physicians can request to add medical conditions to the list, set standards for pulmonary inhalation medical devices prescribed under the program, and establish a timeline for reviewing and approving such devices.”

Under the rule, doctors would submit recommended medical cannabis qualifying conditions to the Department of State Health Services (DSHS), which would then forward the recommendation to DPS. That department would be tasked with submitting the request to lawmakers for consideration in the next legislative session.

The rules must be finalized by October 1, 2025.

In addition to increasing the number of dispensaries, revising physician recommendation policies and setting standards for vaping devises, the law signed by the governor also expands the state’s list of medical cannabis qualifying conditions to include chronic pain, traumatic brain injury (TBI), Crohn’s disease and other inflammatory bowel diseases, while also allowing end-of-life patients in palliative or hospice care to use marijuana.

That policy change will be automatically adopted via the enacted statute when the law takes effect on September 1, so it will not require further rulemaking.

DPS, for its part, will ultimately be issuing 12 new licenses for dispensaries across the state. Currently there are only three. The additional licensees will go through a competitive process, with officials prioritizing Texas’s public health regions to optimize access.

The first round of licenses will be awarded to nine of 139 applicants who submitted their forms during an earlier application window in 2023. DPS will select those nine licensees on December 1. The 2023 applicants that didn’t receive a license, as well as any new prospective licensees, will have another shot at getting their license during a second round where awardees will be announced on April 1, 2026.

The 2023 group can still revise their applications up until September 15. New would-be dispensary owners have until that date to submit their applications as well.

The Department of Public Safety has separately previewed future rulemaking to comply with the medical marijuana expansion law.

That includes proposals to establish “security requirements for dispensing organization satellite locations if approved by the department,” creating rules to revoke licenses for dispensaries that fail to dispense cannabis within two years of a license issuance and setting a timeline for “reviewing and taking action on dispensing organization licenses.”

Meanwhile, Texas lawmakers took up a bill on Wednesday that would ban consumable hemp products containing THC. But despite the committee hearing being held, the legislation isn’t expected to advance during an ongoing special session as Democratic state lawmakers continue to deny the House a quorum to pass any measures amid a conflict over proposed redistricting.

The House bill, a companion to an identical Senate-passed hemp proposal, was discussed during a lengthy meeting of the House Public Health Committee, which is able to conduct business despite the broader lack of quorum in the chamber. While the governor has threatened prosecution or dismissal of absent Democratic members, the walkout hasn’t shown signs of relenting.

Time is running short in the special session the governor convened to address a series of outstanding issues, including legislation related to hemp cannabinoid products. Abbott vetoed an earlier version of the controversial ban that passed during this year’s regular session, and he recently outlined what he’d like to see in a revised version of the bill.

The governor and legislative leaders have since affirmed that, if Democrats members don’t show up and establish a quorum by Friday, they will end the current special session and start a new one. Under the state constitution, special sessions cannot last longer than 30 days, but there is no limit to how many can be called.

At a press conference last month, a group of Democratic state senators introduced two new cannabis-related bills, including one that would regulate the hemp market, allowing adults 21 and older to purchase hemp products containing no more than 5 mg of THC per serving.

A second new bill would effectively legalize cannabis for adult use by removing criminal penalties for possession of up to two ounces of marijuana on a person and up to 10 ounces in a single household if it’s secure and out of sight. Cultivation of up to six plants, only half of which could be mature, would also be legalized.

The governor, who during the state’s regular legislative session this year vetoed a similar hemp product ban, SB 3, has also backed the idea of limiting THC potency and prohibiting sales to minors rather than outlawing products entirely.

Under the current Senate-passed proposal, consumable hemp products with any amount of THC—or any other cannabinoid besides CBD and CBG—would be illegal. Even mere possession would be punishable as a Class B misdemeanor, carrying up to 180 days in jail and a $2,000 fine.

Some advocates are hopeful that either SB 5 or its House counterpart could see revisions as they make their way through the legislative process—either to affirmatively regulate the hemp market or to at least ease some of the criminal penalties on individuals found in possession of the affected products.


Marijuana Moment is tracking hundreds of cannabis, psychedelics and drug policy bills in state legislatures and Congress this year. Patreon supporters pledging at least $25/month get access to our interactive maps, charts and hearing calendar so they don’t miss any developments.


Learn more about our marijuana bill tracker and become a supporter on Patreon to get access.

Separately, Rep. Nicole Collier (D) introduced a one-page bill, HB 42, designed to protect consumers in the state from criminal charges if what they believed was a legal hemp product turned out to contain excessive amounts of THC, making it illegal marijuana. It would prevent the criminalization of someone found in possession of a product that’s labeled as hemp but is determined to contain “a controlled substance or marihuana.”

In order for the person to obtain the legal protection, the product would need to have been purchased “from a retailer the person reasonably believed was authorized to sell a consumable hemp product.”

Another bill—HB 195, introduced by Rep. Jessica González (D)—would legalize marijuana for people 21 and older, allowing possession of up to 2.5 ounces of cannabis, with no more than 15 grams of that amount being in concentrated form.

Yet another proposal would order state officials to conduct a study on testing for THC intoxication.

As for what Texans themselves want to see from their representatives, proponents of reining in the largely unregulated intoxicating hemp industry in Texas shared new polling data indicating that majorities of respondents from both major political parties support outlawing synthetic cannabinoids, such as delta-8 THC.

The survey also found that respondents would rather obtain therapeutic cannabis products through a state-licensed medical marijuana program than from a “smoke shop selling unregulated and untested hemp.”

Ahead of the governor’s veto in June of SB 3—the earlier hemp product ban—advocates and stakeholders had delivered more than 100,000 petition signatures asking Abbott to reject the measure. Critics argued that the industry—which employs an estimated 53,000 people—would be decimated if the measure became law.

Photo courtesy of Philip Steffan.

Marijuana Moment is made possible with support from readers. If you rely on our cannabis advocacy journalism to stay informed, please consider a monthly Patreon pledge.

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Can Cannabis Help Make The Brain Younger

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The age old search for youth may have a new direction – marijuana

The fight to stay young and healthy has been going on for hundreds if not thousands of years. Billions have been spent, but now there is a new twist – can cannabis help make the brain younger. In the age of biohacking and wellness trends, millennials juggling Zoom fatigue and daily stress are asking: can cannabis do more than chill us out—might it actually make our brains feel younger?

RELATED: Marijuana Might Be A Better Hurricane Party Guest

Preclinical research has shown striking results: in older mice, low-dose THC boosted synaptic connectivity and improved memory, seemingly reversing age-linked cognitive decline.

On the human front, a controlled trial at Johns Hopkins and Tufts used dronabinol—a synthetic THC—in 75 Alzheimer’s patients experiencing agitation. Over three weeks, a twice-daily 5 mg dose reduced agitation by about 30% and was better tolerated than traditional antipsychotics.

A peaceful sleeping baby nestled in a soft, fluffy blanket inside a wicker basket.

However, when it comes to cognitive effects in healthy or aging adults, the data is more mixed. A JAMA Network Open study tracked 57 new medical cannabis users for a year using fMRI scans. The result? No meaningful changes in working memory, reward processing, or inhibitory control—good news for safety-minded users.

But another large-scale imaging study found among young adults (ages 22–36), heavy cannabis users showed reduced brain activation during working memory tasks—63% in lifetime users and 68% in recent users.

Long-term studies add nuance: a Danish cohort study followed over 5,000 men from young adulthood to their 60s and found no greater cognitive decline among cannabis users—in fact, users showed slightly less IQ decline than non-users

RELATED: Science Says Medical Marijuana Improves Quality Of Life

What Does It All Mean for the average person?

  • Dronabinol may soothe brain agitation in Alzheimer’s patients—a meaningful bump in quality of life for patients and caregivers Johns Hopkins Medicine.

  • Medical cannabis over a year doesn’t appear to disrupt key cognitive functions in healthy adults, based on fMRI measures.

  • Heavy recreational use, especially among the younger crowd, may impair working memory and brain activity in imaging studies

  • Long-term cognitive aging trends may not suffer—and could potentially fare better—in users, according to a large Danish study.

While animal studies highlight a fascinating possibility—THC under tightly controlled, low doses might rewind aspects of brain aging— human trials are still in early stages. For Alzheimer’s-related agitation, synthetic THC shows real promise. For healthy adults, cannabis appears neurologically safe over a year. Yet, heavy habitual use—particularly among younger individuals—may carry cognitive costs. Conversely, long-term cognitive aging does not seem accelerated among users—and might even be subtly mitigated.



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Klutch Cannabis Opening 5th Ohio Dispensary in Northfield

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[PRESS RELEASE] – NORTHFIELD VILLAGE, Ohio, Aug. 15, 2025 – Klutch Cannabis, one of Ohio’s leading vertically integrated cannabis companies, announced the grand opening of its newest dispensary, located at 10650 Northfield Road in Northfield Village, Ohio. Doors will officially open at 10 a.m. Aug. 21, 2025.

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The new location marks Klutch’s first dispensary in Summit County, where the company is headquartered. Conveniently situated directly across the street from the MGM Northfield Park Casino and Racetrack, the dispensary is easily accessible from Route 8 and I-271, finally bringing much-needed access to medical cannabis patients and adult-use consumers in Northern Summit County communities, including Northfield Village, Macedonia, Northfield Center Township, Twinsburg, Hudson, Sagamore Hills, Boston Township, Richfield Township, Bath Township, and more.

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The expansion further solidifies Klutch’s retail footprint in Northeast Ohio and represents an important milestone as the company begins delivering its renowned top-shelf products on its home turf. Offerings will include exclusive drops and limited releases along with customer favorites from the company’s Klutch Cannabis and Habitat by Klutch lines, its Ohio-exclusive brand partners, and other Ohio cannabis companies. The Northfield dispensary will also feature Klutch’s signature aesthetic and exceptional customer service, as well as a convenient drive-thru pickup window for pre-orders.

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Hours of operation for the new Northfield Village location will be:

  • 10 a.m. to 10:45 p.m. Thursday through Saturday
  • 10 a.m. to 10 p.m. Sunday through Wednesday
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“We’re incredibly excited to expand Klutch Cannabis’s retail footprint to Summit County,” Klutch founder and CEO Adam Thomarios said. “This location has been years in the making and will finally provide patients and adult-use customers in Northern Summit County with access to the quality, care, and consistency that Klutch is known for. Our thanks go out, especially, to the community, administration, and officials in Northfield Village for being such great partners from the start. The Village is a great place to do business, and we can’t wait to start making a positive impact in the community.”

For more information about Klutch Cannabis, its dispensaries, and its award-winning products, visit KlutchCannabis.com and HabitatbyKlutch.com or follow @KlutchxCommunity and @HabitatbyKlutch on Instagram.



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