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Microdosing LSD Can Help Treat Separation Anxiety In Dogs, New Case Study Suggests

Published
2 weeks agoon

A new case study in the journal Veterinary Medicine and Science suggests that very small doses of the psychedelic LSD appeared to ease a dog’s severe separation anxiety, reducing destructive behavior and shortening the duration of vocalizations.
Authors of the report said the results “suggest potential therapeutic efficacy of microdosing 1cp-LSD in managing canine anxiety,” though they acknowledged that future research is needed to validate the findings. They point out that anxiety is “prevalent in dogs, affecting an estimated one-fifth of the canine population.”
The subject of the new study was a 13-year-old female dog of mixed breed, whom researchers had previously administered a single microdose of 1cP-LSD—a semi-synthetic analogue of LSD with very similar psychoactive effects—”to observe the effects of the drug in the canine species, as no literature existed on this matter,” the paper says.
Results of the earlier experiment indicated the drug was “safe and effectively reduced anxiety in the animal,” authors wrote.
The current study evaluated the dog’s separation anxiety and how it changed over the course of a monthlong LSD treatment regimen. Using a points-based scale, researchers said the dog’s “anxiety score significantly decreased from 29 (severe) to 14 (moderate) after treatment.”
“A reduction in anxiety levels was observed, characterized by decreased destructive behaviour and shorter durations of vocalization,” authors wrote. “This improvement was sustained 1 month following treatment, although vocalization frequency increased.”
Treatment consisted of administering 5 micrograms of 1cP-LSD—or about 0.38 nanograms per kilogram of body weight—orally to the dog every three days, which amounted to 10 total doses over the course of the month. “The substance was administered by disguising it in a piece of ham and delivered orally to the animal at breakfast time,” the report says.
“Since no pharmacokinetic studies of LSD have been conducted in dogs,” authors explained, “the selected dose was extrapolated from human data, acknowledging potential interspecies differences in substance metabolism and effect.”
They added that no adverse effects were recorded over the course of treatment.
Authors—from the Universidad de Las Palmas de Gran Canaria and Asociación Científica Psicodélica, in the Canary Islands—acknowledged that the study’s “key limitation” was its lack of a placebo-controlled, blinded design. The team nevertheless implemented “methodological precautions” meant to reduce bias, they said, such as assessing anxiety through “validated behavioural scales” and evaluating both the owner’s subjective observations as well as “objective indicators, such as vocalization duration and destructive behaviours.”
They also noted that the use of psychedelics in non-human animals could raise questions about informed consent and “the ability of animals to comprehend the nature and purpose of the study.”
“While this study aimed to explore the potential therapeutic benefits of these substances, it is crucial to acknowledge the potential impact on animal welfare,” they wrote. “The long-term effects of repeated psychedelic administration in animals are unknown, and further research is needed to assess potential adverse effects.”
Results of the new pilot study were nevertheless promising, the report concludes.
“The administration of 5 µg of 1cp-LSD once every 3 days over a 30-day period was associated with a reduction in severe anxiety to a moderate level in a female dog, with the effect persisting for 1 month posttreatment,” it says, adding, however, that “Given the exploratory nature of this single-case study, these findings should be interpreted with caution.”
While the team’s focus on LSD is novel in a variety of ways, there’s been growing interest within the scientific community about potential treatment alternatives for pets and other animals, including with cannabis.
For example, the National Animal Supplement Council (NASC) promoted a study last year that it said shows CBD is “safe for long-term use” in dogs—a significant finding given emerging research that cannabis can effectively treat conditions such as anxiety and certain skin diseases among canines.
Another 2024 case study found that cannabis appears to be a “viable alternative” treatment option for dogs suffering from a common skin disease, especially if they experience adverse side effects from conventional steroid therapies.
A separate study late last year, meanwhile, found that giving dogs a dose of CBD could help counteract the ill effects of accidental THC consumption.
Authors of that report said reducing the cost of treating THC toxicosis is especially important given that cases of accidental marijuana exposure have been increasing in recent years and that the inability to afford emergency services is “a leading barrier to accessing veterinary care in both the United States and Canada.”
Earlier this year, the U.S. Food and Drug Administration (FDA) sought input from veterinarians and the broader public about the use of cannabis-derived products—in particular CBD—in animals. The agency wanted to know more about usage trends, potential drug interactions, quality standards and other issues related to the veterinary use of cannabinoids.
The input is meant to help inform the Center for Veterinary Medicine’s (CVM) “knowledge of potential safety signals associated with these products, in addition to aiding our understanding of veterinarians’ experiences related to the use of CDPs [cannabis-derived products] for their animal patients,” the FDA filing said.
“FDA has made the regulation of the CBD market a priority, including products marketed for animals,” it added. “While there is some limited published information about use of CDPs in animals, significant data gaps exist surrounding many aspects of CBD and other CDPs in animals.”
Among other relevant research, a study published in early 2023 found that dogs that receive daily doses of CBD see “significant reductions” in stress and anxiety related to car travel.
Other studies have demonstrated benefits of CBD such as reduced frequency of seizures among dogs who receive the cannabinoid, while a study published in 2018 found that CBD treatment appeared to improve canine arthritis.
Last August, the U.S. Department of Agriculture (USDA) found that cows that are fed hempseed cake retain very low concentrations of THC and CBD in their bodies, indicating that meat products from hemp-fed cattle are safe for human consumption.
Another federally funded study published in 2022 found that feeding cows hemp reduces their stress. Researchers have also looked into how CBD affects stress and pain in horses.
Photo courtesy of Pexels.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.
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12 New York Cannabis Businesses Sue State Over School Proximity Fiasco

Published
36 minutes agoon
August 18, 2025
A dozen New York-licensed cannabis dispensaries are taking regulators to court over a screw-up by the state’s Office of Cannabis Management (OCM) related to their storefront locations being too close to schools.
The 12 petitioners filed the complaint on Aug. 15 in the New York Supreme Court in Albany County, against the OCM and the state’s Cannabis Control Board (CCB) over a school proximity correction that the office issued July 28. The correction, which impacts 108 dispensary licensees and 44 applicants with provisional licenses, intends to realign the OCM’s 500-foot measurement guidelines with state law.
Instead of continuing an entrance-to-entrance measurement between dispensaries and schools from the OCM’s erroneous 2022 guidance, the office now plans to measure the buffer zone from the entrance of a cannabis store in a straight line to the nearest property line boundary of a school’s grounds to move into compliance with New York’s cannabis law.
Following the proximity correction issuance, OCM Acting Executive Director Felicia A.B. Reid sent a letter on Aug. 6 to the 152 impacted businesses, clarifying that the 108 licensees may remain open or continue to work toward opening in their current locations as state officials push lawmakers for a legislative fix to grandfather in their locations. The 44 applicants, meanwhile, will need to move locations and will have access to $250,000 each from a $15 million relief fund to lessen their burdens.
Despite the assurance that the 108 licensees can remain put—and even continue to operate while the OCM delays reviewing any license renewals pending the legislative fix—the petitioners are asking the state Supreme Court in Albany to annul the OCM’s revised interpretation of Cannabis Law § 72(6) and declare that their locations remain compliant under a lawful reading of that law as well as the OCM’s 2022 guidance.
The 12 cannabis businesses are also asking that a State Supreme Court judge issue a preliminary and permanent injunction preventing the OCM from taking any enforcement actions against them based on the office’s new interpretation of the law, forcing the OCM to instead keep its previous interpretation that regulators used to review and approve site plans to issue licenses.
“Relying on those approvals, petitioners poured their life savings into launching their businesses,” the complaint states. “They signed leases, completed build-outs, hired employees and opened their doors to the public under the state’s very detailed framework. But now, in a complete about-face, OCM incredulously claims it got the law wrong all along.”
Furthermore, the petitioners claim that the OCM changed its guidance based on a new interpretation of the law without any formal rulemaking process or public notice. They argue that the informal rulemaking violates the State Administrative Procedure Act and that state officials arbitrarily redefined their own regulations.
Seven of the 12 businesses suing the state are either open or have received their final licensure to open, meaning the state has assured them they do not need to move locations and can remain open even with expired licenses—the OCM indicated it cannot approve their license renewals until state lawmakers act. However, some businesses fear that insurance companies and banks may refuse to service them if their licenses have expired, even in an interim phase.
“Petitioners face numerous collateral consequences as a result of OCM’s unlawful reinterpretation of Cannabis Law §72(6),” the complaint states. “Specifically, petitioners are required as part of their leases to be in compliance with all cannabis laws. OCM’s arbitrary and capricious actions have placed them at risk of falling into material breach with their lessors and, if allowed to continue, will cause them irreparable harm.”
These seven businesses include: ConBud (Manhattan), The Cannabis Place (Queens), Summit Canna (Bronx), Hush (Bronx), High Fade (Manhattan), Housing Works Cannabis Co. (Manhattan) and Common Courtesy Dispensary (Queens).
Meanwhile, the other five petitioners in the lawsuit are cannabis business applicants who received provisional licenses that are not yet finalized and will therefore be forced to pack up and change locations. These businesses include: Rezidue, Elise Pelka, Toastree, Monarch NYC and Luxe Leaf Boutique.
According to the lawsuit, while each of the five applicants has incurred significant buildout expenses, Rezidue, Elisa Pelka and Lux Leaf Boutique have completed their buildouts and were ready to begin operating upon a virtual inspection and gaining final licensure.
The petitioners’ construction costs ranged from $500,000 to $1,000,000, falling short of the $250,000 available per applicant in the state’s relief fund, according to the lawsuit.
“Petitioners have each expended nearly and in some cases over $1 million in preoperational expenses, and several million dollars each in post-operational expenses in reliance of OCM’s assurances,” the complaint states. “If OCM’s new and unlawful interpretation is allowed to remain in force, petitioners will also lose hundreds of thousands of dollars in deposits and lease termination penalties that cannot be recouped.
“Additionally, petitioners have all executed personal guarantees on their commercial leases, which would not only bankrupt the businesses, but also the individuals who guaranteed these leases.”
The petitioners argue that these expenses represent irreparable harm, which the court has the authority to prevent.
Other arguments the 12 cannabis businesses made in the lawsuit include:
- Retroactively revoking their license rights without notice or hearing violates due process;
- The OCM violated the equal protection clause of the state’s Constitution by revoking their proximity protections and thereby allowing competing applicants to gain favorable locations (in addition to the 500-foot school buffer zone, dispensaries must adhere to bigger buffer zones between other dispensaries).
- By pre-emptively denying licensees renewals, the OCM has engaged in unlawful “taking” without affording the petitioners due process of the law by way of a fair hearing;
- The plaintiffs’ investments have been rendered valueless by the OCM’s retroactive policy change, amounting to a “regulatory taking” under the New York Constitution; and
- The OCM’s new interpretation of the state’s cannabis law as it relates to school proximity requirements disproportionately harms those who were already disproportionately harmed by the drug war, which violates the state’s Marihuana Taxation and Regulation Act (MRTA) provisions to prioritize the inclusion, participation and sustainability of equity applicants.
“OCM’s reinterpreted rule disproportionately harms these stakeholders and licensees and undermines the very purpose of this law,” the complaint states about the latter bullet point. “Petitioners do not come from generational wealth and therefore cannot sustain such a hit. Their lives would be shattered while the OCM simply says ‘I’m sorry.’”
In particular, 11 of the plaintiffs are conditional adult-use retail dispensary (CAURD) licensees who were prioritized by the state because their businesses were owned by justice-involved individuals who reside in New York.
The 12th plaintiff is a social and economic equity (SEE) licensee, a category reserved for justice-involved individuals, minority- or women-owned businesses, distressed farmers, or service-disabled veteran-owned businesses.
“Petitioners would experience harm unlike anything they have faced before and would be relegated to levels of crippling debt, the likes of which they could never escape,” the complaint states. “The purpose of the MRTA was to undo these past injustices, not to exacerbate them.”

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.
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Massachusetts Auditor Notes ‘Violations’ and ‘Mismanagement’ At Cannabis Control Commission

Published
2 hours agoon
August 18, 2025
Massachusetts Auditor Diana DiZoglio last week released an audit of the state’s Cannabis Control Commission (CCC), claiming to have uncovered violations and mismanagement issues at the commission, NBC Boston reports.
The audit found that officials “failed to take appropriate steps and institute procedures” to guarantee the administering of cannabis industry license extensions, and that a “lack of supervision and minimal accountability over licensing staff members” helped contribute to the breakdown.
“CCC’s mismanagement of prorated fees for license extensions resulted in procedural inequity, revenue loss, and noncompliance with state regulations.” — Excerpt from the audit summary
The commission said it has “been working closely with the State Auditor’s Office for almost a year and will review the report released today in furtherance of our shared commitment to government improvement. Over the course of the audit period and since, the Commission has hired key leaders, made progress to address many of the issues referenced, and begun to move forward in a constructive way.”
The report was released hours after the commission voted unanimously to reinstate the license of Assured Testing, a testing lab accused of failing to report thousands of contaminated cannabis samples, the report said. The commission issued penalties against the lab, including a $300,000 fine and two years of probation. Additionally, the lab — which has publicly disagreed with the findings but says it will honor the commission’s terms for reinstatement — will have to hire an independent auditor, an internal control manager, and a new interim CEO.
“We are eager to return to what we do best: delivering scientific, evidence-backed testing with industry-leading cannabis expertise,” Assured Testing said in a statement.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.
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Supreme Court Gives Marijuana Companies More Time To File Petition In Case Challenging Federal Prohibition

Published
3 hours agoon
August 18, 2025
The U.S. Supreme Court has granted a request to give marijuana companies suing the Justice Department in an effort to overturn federal prohibition two more months to file their petition with the justices.
Lawyers for the cannabis firms said the extension was needed due to the “significant and complex constitutional issues” that are being raised in the case, as well as the fact that state governments and other experts who plan to file support briefs need more time to “carefully craft their arguments.”
The prominent litigation firm Boies Schiller Flexner LLP that’s representing the companies—Canna Provisions, Gyasi Sellers, Wiseacre Farm and Verano Holdings—entered a request for a 60-day extension to submit its writ of certiorari last week. Justice Ketanji Brown Jackson approved the proposal on Friday, pushing back the current deadline of August 25 to October 24.
The companies’ request noted that counsel for the Office of the Solicitor General don’t oppose the extension.
The brief gave three reasons for the request: 1) the lead attorney on the case, David Boies, is “heavily engaged in previously scheduled matters” before other federal courts, 2) several experts who expressed interest in supporting their lawsuit with amicus briefs have said they need more time and 3) the case involves complex legal issues that require more in-depth consideration.
“This case presents significant and complex constitutional issues concerning both state-regulated marijuana specifically and the authority of Congress to regulate purely intrastate commerce generally,” the filing says. “The additional time will permit counsel to prepare a petition that appropriately addresses the questions of nationwide importance raised by this case.”
That includes “the question of whether [Gonzales v. Raich] was correctly decided,” it says, referencing a landmark 2005 Supreme Court ruling, wherein justices narrowly determined that the federal government could enforce prohibition against cannabis cultivation that took place wholly within California based on Congress’s authority to regulate interstate commerce.
With respect to future amicus briefs the applicants are expecting, they said “counsel have heard from law professors, non-profits, state governments, and others interested in submitting amicus briefs in these proceedings, and several of these potential amici have expressed concern about having sufficient time to prepare over the summer.”
“An extension will provide potential amici adequate time to consider the case and carefully craft their arguments,” the filing says.
This comes about three months after a U.S. appeals court rejected the arguments of the state-legal cannabis companies, one the latest blow to the high-profile lawsuit following a lower court’s dismissal of the claims. But it’s widely understood that the plaintiffs’ legal team has long intended the matter to end up before the nine justices.
“It’s fair to assume that we shall seek Supreme Court review,” attorney Jonathan Schiller told Marijuana Moment in June.
The latest filing concludes by saying respondents “will not suffer any prejudice from the requested extension,” and because “the First Circuit affirmed the dismissal of Applicants’ claims, a brief extension will not in any way alter the status quo of this case.”
While it remains to be seen whether the high court will ultimately take the case, one sign that at least some on court might be interested in the appeal is a 2021 statement from Justice Clarence Thomas, issued as the court denied review of a separate dispute involving a Colorado medical marijuana dispensary.
Thomas’s comments seemed to suggest that it’d be appropriate revisit Raich—a move that could largely upend federal prohibition.
The statement pointed to policy developments since the earlier case was decided, such as the hands-off enforcement approach taken by the Department of Justice as more states legalized cannabis and a congressional budget rider protecting state-legal medical marijuana programs.
“Whatever the merits of Raich when it was decided, federal policies of the past 16 years have greatly undermined its reasoning,” Thomas wrote, describing the government’s approach to cannabis enforcement as “a half-in, half-out regime that simultaneously tolerates and forbids local use of marijuana.”
“Though federal law still flatly forbids the intrastate possession, cultivation, or distribution of marijuana…the Government, post-Raich, has sent mixed signals on its views,” the justice continued, saying the situation “strains basic principles of federalism and conceals traps for the unwary.”
Once plaintiffs in the case at hand file their forthcoming petition for a writ of certiorari, it would need needs the votes of four justices to put the case before the Supreme Court.
The initial complaint, filed in U.S. District Court for the District of Massachusetts, argued that government’s ongoing prohibition on marijuana under the Controlled Substances Act (CSA) was unconstitutional because Congress in recent decades had “dropped any assumption that federal control of state-regulated marijuana is necessary.”
At oral argument on appeal late last year, Boies told judges that under the Constitution, Congress can only regulate commercial activity within a state—in this case, around marijuana—if the failure to regulate that in-state activity “would substantially interfere [with] or undermine legitimate congressional regulation of interstate commerce.”
Judges, however, said they were “unpersuaded,” ruling in last month’s opinion that “the CSA remains fully intact as to the regulation of the commercial activity involving marijuana for non-medical purposes, which is the activity in which the appellants, by their own account, are engaged.”
The district court, meanwhile, said in the case that while the there are “persuasive reasons for a reexamination” of the current scheduling of cannabis, its hands were effectively tied by past U.S. Supreme Court precedent in Raich.
Meanwhile, amid a series of legal challenges, the Trump administration recently asked the Supreme Court to take up a case on the federal government’s ban on users of marijuana and other illegal drugs from owning firearms and uphold the prohibition, saying it is consistent with the Second Amendment.
Separately at the federal level, a pending Biden-era recommendation to reschedule marijuana to the less restrictive Schedule III of the CSA is remains stalled.
The MAGA world is divided on how it wants President Donald Trump to come down on that proposal, with key right-wing influencers voicing conflicting positions on the issue after the president announced an imminent decision last week.
While Trump endorsed moving marijuana to Schedule III during last year’s presidential campaign—along with cannabis industry banking access and a Florida legalization ballot initiative that ultimately fell short—last week he merely said he is considering the issue, with a decision expected within weeks.
The overall bipartisanship of the issue, however, was also reflected in recent comments from one Democratic and one Republican member of Congress, who urged Trump to federally reschedule marijuana.
A new political committee that shares the same treasurer as Trump’s own super PAC is also pushing the president to follow through on rescheduling marijuana, releasing an ad that highlights his previous endorsement of the reform on the campaign trail.
Photo elements courtesy of rawpixel and Philip Steffan.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.

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