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Lykos Therapeutics CEO Amy Emerson steps down

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Privately-owned Lykos Therapeutics continues to reel from its devastating rejection by the Food & Drug Administration (FDA) for the company’s MDMA drug. The company announced that its Chief Executive Officer Amy Emerson is stepping down from her role and will transition into a senior advisor role through the end of the year. She will also serve as an Observer on the Lykos Board.

Michael Mullette, who has served as Chief Operating Officer (COO) since early 2022 will become the company’s interim CEO. According to the company’s statement, Mullette joined Lykos after more than two decades in the pharmaceutical industry, most recently heading North America for Moderna, where he oversaw commercialization of the company’s COVID-19 vaccine during the height of the pandemic.

“Mike is a highly experienced leader with the right background and skills to steer Lykos as we engage with the FDA and work to bring this pioneering treatment to patients in need,” said Jeff George, Chairman of the Lykos Board of Directors. “Mike has been highly impactful in his role as COO and has a deep understanding of the path ahead. He brings a wealth of knowledge and an impressive track record from over two decades in pharmaceuticals and is well-equipped to lead Lykos as we look to the future.”

In addition to Mullette’s appointment, Dr. David Hough, who was recently announced as Lykos’ senior medical advisor, formally joins the company as Chief Medical Officer. Dr. Hough will continue to oversee Lykos’ clinical development program and its regulatory engagement with the FDA regarding the resubmission of midomafetamine. Lykos told the marketplace that Dr. Hough previously spent 17 years with Johnson & Johnson, where he oversaw the Spravato (esketamine) Phase 3 development and approval in two indications across multiple markets.

Emerson had been the CEO at Lykos for nearly 10 years. She began work on the midomafetamine program in 2003 and was appointed to lead Lykos (then MAPS PBC) upon its formation in 2014.

“We founded Lykos with a deep belief in the need for innovation in mental health, and I am deeply grateful for the privilege of leading our efforts,” said Ms. Emerson. “While we are not at the finish line, the past decade of progress has been monumental. Mike has been an outstanding partner and is well-prepared to step in and lead our next steps. I know he will continue to pursue Lykos’ mission of helping patients with unwavering dedication and resolve.”

Restructuring

Last month, Green Market Report wrote that Lykos Therapeutics announced a reorganization plan in the wake of the federal government’s rejection of its application for its MDMA-based drug designed to treat post-traumatic stress disorder. However, the company promised stakeholders that it was not giving up. It cut its staff by roughly 75%, with those left focusing their time and resources on getting FDA approval for the MDMA capsules.

The final portion of the reorganization plan called for the departure of Dr. Rick Doblin, the founder of the Multidisciplinary Association for Psychedelic Studies (MAPS), from Lykos’ board of directors.



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High Tide fine-tunes playbook as Canadian cannabis rivals struggle

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Calgary-based High Tide Inc. (Nasdaq: HITI) (TXSV: HITI) continues to grow its store count alongside its balance sheet, all while some of its largest competitors file for bankruptcy or shutter locations amid industry headwinds.

On an earnings call Monday, High Tide CEO Raj Grover said the company has opened 21 new stores so far this year and expects to reach the upper end of its guidance for 20-30 new locations in 2024. That  optimism comes as major rivals like Tokyo Smoke and Fire & Flower have filed for creditor protection or closed numerous stores.

“We found our secret mantra of growing organically,” Grover told analysts.

The expansion comes as High Tide reported reaching 12% market share in the provinces where it operates, up from 10% a year ago.

Meanwhile, Tokyo Smoke recently announced plans to close 29 of its roughly 100 stores after filing for creditor protection. Fire & Flower shuttered over 60 locations this year as part of restructuring efforts.

“Fire & Flower, Kiaro, Trees, Tokyo Smoke — I can keep going … ShinyBud,” he said. “There (are) endless companies that have gone bankrupt.”

Grover attributed some competitors’ struggles to poor real estate decisions and unfavorable lease terms, in addition to “how they’ve managed their operating expenses.”

“But again, let me remind everyone listening on this call that these companies are not going bankrupt because they’ve done a great job on site selection criteria and the size of these units and the rental rates that they’re paying,” he said.

He noted that High Tide spends just $260,000 to build out new locations plus about $100,000 for inventory and working capital. That allows the company to “cherry pick” prime locations and achieve “better, higher quality growth” compared to acquisitions.

He pointed out examples of rivals leasing oversized stores at inflated rates.

“I look at a lot of these stores with our real estate team, and I’m shocked sometimes to see a 3,000, 4,000, 5,000-square-foot store in Canada pop up,” he said. “Who’s going to take that at $100 a square foot, even if it’s in the best location ever?”

High Tide’s adopted a more disciplined approach, targeting smaller (typically around 1,500 square foot) locations with favorable rents.

“We like quality locations, we like square footages that we can live with, and we like rental rates that can stand the test of time, which is an opportunity for the landlord and the tenant and not one directional,” Grover said.

That strategy has allowed the company to generate positive free cash flow for five straight quarters even while expanding its store count to 183 locations.

That’s not to say that High Tide won’t make acquisitions; it’s just very selective and deliberate in  its consideration of struggling competitors’ locations.

“As much as we are in these portfolios, the opportunities are thin because we don’t want to get a 3,000- to 4,000-square-foot store paying $80, $90 a square foot,” Grover said. “It defeats the purpose of just making an announcement that we took over 10 Tokyo Smoke stores. I’m not taking over that pain and bringing it over to High Tide.”

He added: “A lot of these leases were signed when legalization took place in 2018 or even prior in some cases, and those groups are licking their wounds. It’s not a good place to be in.”

Still, execs cited a resurgence of illicit cannabis stores that are adding pressure on legal sales in some markets. Grover said there are an estimated 200 illegal shops that have opened across Canada since the start of 2024.

“We have to hold the line on the illicit market,” he said, noting High Tide had to cut margins by 5-7% in Regina, Saskatchewan, after several unlicensed stores opened nearby. The company is pushing governments to step up enforcement efforts.



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New Cannabis Legalization Introduced To PA Legislature – Cannabis Business Executive

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Eye in the Sky: Neatleaf is Watching Your Plants – Cannabis Business Executive

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