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It’s Epilepsy Awareness Day as cannabis treatment studies continue

Published
1 week agoon

Purple Day, the international epilepsy awareness day, is today and it encourages people to wear purple and engage in activities to raise awareness about epilepsy. The modern-day cannabis industry was effectively launched when it was determined that medical marijuana was effective at treating the disease.
Going back in time, a 60 Minutes segment on the little girl Charlotte Figi, who suffered from a rare epileptic disease called Dravet Syndrome, took medical marijuana to treat her seizures. The segment featured Dr. Sanjay Gupta and demonstrated the quick effectiveness that a high-CBD and low-THC strain had on the child. Her seizures relented almost immediately. The powerful video footage prompted many legislators to consider medical marijuana as a treatment.
She was treated in Colorado with a strain that was initially called Hippie’s Disappointment because of its low THC level, but was eventually renamed Charlotte’s Web and was grown by the Stanley Brothers. Many families of children with the disease moved to the state for treatment and Colorado became ground zero for the creation of a regulated legal cannabis program.
Cannabis companies emerge
Charlotte’s Web
Charlotte’s Web (OTC: CWBHF) initially saw big success with its CBD products as the company was a well-respected brand with the connection to the high-profile story. However, massive competition has hurt the company. It recently reported earnings and Charlotte’s Web saw its full-year revenue decline by 21.4% versus 2023. The company reported $49.7 million in annual revenue for 2024, down from $63.2 million in 2023. Harking back to its medical days, the company also told investors it reached a regulatory milestone through its investment in DeFloria, which received FDA clearance in February 2025 to proceed with Phase 2 clinical trials for a botanical pharmaceutical candidate targeting symptoms of autism spectrum disorder.
DeFloria is a collaboration including Charlotte’s Web and Ajna BioSciences PBC, a botanical drug development company, to develop AJA001 as a treatment for irritability associated with autism spectrum disorder. AJA001 employs Charlotte’s Web proprietary full-spectrum cannabidiol (CBD) hemp extract derived from one of its patented cultivars. The company hopes for a botanical solution to the disorder, which would help even more children.
Jazz Pharmaceuticals
GW Pharmaceuticals really legitimized medical marijuana with its drug Epidiolex. This drug passed through the stringent FDA study trials and is now a prescription drug that treats rare pediatric epilepsy diseases, Dravet Syndrome and Lennox-Gastaut. It is often cited as a reason why cannabis should no longer be a Schedule 1 drug under the Controlled Substances Act. Jazz Pharmaceuticals (NASDAQ: JAZZ) acquired GW Pharmaceuticals in 2021 in a deal valued at $7.2 billion. Jazz recently reported that its net product sales of Epidiolex/Epidyolex in 2024 were $972.4 million, which represented 25% of its total net product sales for the year.
Tilray
Tiltay may be better known for its beverage products and its exports to Europe, but the company has a dedicated medical division, Tilray Medical, that focuses on medical cannabis research and development. Tilray’s 2:100 has been used off-label for patients as an alternative to Epidiolex. It sells in Canada for C$236 a bottle. The company ships its medical products across the world and it has supported and participated in clinical trials to study the efficacy of medical cannabis in treating epilepsy, including pediatric epilepsy.
Aurora Cannabis
In 2021, Aurora Cannabis Inc. (NASDAQ: ACB) launched Bidiol, the first medical cannabis oil in Uruguay that was wholly produced domestically. The oil is authorized by the Ministry of Public Health of Uruguay for the treatment of refractory epilepsy in children and adolescents.
Zynerba Pharmaceuticals
Zynerba produced Zygel, a CBD-based transdermal gel developed for Fragile X syndrome and other neuropsychiatric conditions, including some seizure disorders. The company was acquired by Harmony Biosciences and it continues the work on its synthetic CBD compound.
Looking Ahead
Two national NHS clinical trials are set to begin this year, focusing on the safety and effectiveness of cannabidiol (CBD) and tetrahydrocannabinol (THC) in adults and children with treatment-resistant epilepsy. It will be led by Professors Finbar O’Callaghan and Helen Cross from University College London (UCL) and Great Ormond Street Hospital (GOSH). According to Epilepsy Action, these trials aim to provide comprehensive data to address questions posed by the National Institute for Health and Care Excellence (NICE) regarding cannabinoid treatments.
Jazz Pharmaceuticals told investors it has initiated a Phase 3 trial to evaluate the efficacy and safety of Epidiolex in children and adolescents with Epilepsy with Myoclonic-Atonic Seizures (EMAS). This randomized, double-blind, placebo-controlled study aims to assess EMAS-associated seizure frequency over a 14-week treatment period.
A trial in Australia and New Zealand is investigating the use of a cannabidiol transdermal gel for adults with focal epilepsy. This study aims to assess the efficacy and safety of this novel delivery method for CBD in treating the most common, hard-to-treat epilepsy type in adults.
The American Epilepsy Society reported that an open observational prospective study in Buenos Aires included 55 patients with focal drug-resistant epilepsy. Participants began treatment with a purified CBD oil, titrated progressively up to 20 mg/kg/day over six months. The study aims to evaluate the monthly percentage change in seizure frequency.
The cannabis industry was spawned over the desire to help children who faced an unimaginable disease. Without their sacrifice, the industry likely wouldn’t exist in the form that it is in today.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.
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Filament Health to raise nearly C$1M, plans Cboe Canada delisting

Published
2 hours agoon
April 4, 2025
Filament Health Corp. (OTCQB: FLHLF) (Cboe CA: FH) (FSE: 7QS) said that it will raise around C$900,000 via a private placement led by existing investor Negev Capital Fund One and company insiders, while also planning to voluntarily delist from the Cboe Canada exchange – just days after reporting latest challenges including a nearly $5 million annual loss and dwindling cash reserves.
According to a Thursday afternoon news release, the financing will come through units comprised of secured convertible debentures with a 9% annual interest rate and warrants for the purchase of common shares. The debentures will be convertible into common shares at C$0.02 per share, while the warrants will have a 36-month term at an exercise price of C$0.03 per share.
“As a longstanding supporter of Filament Health and its mission, we are pleased to continue our commitment to the company,” Vadim Uzberg, partner at Negev Capital, said in a statement. “Filament remains well-positioned, leveraging its groundbreaking botanical drug development platform and an industry-leading intellectual property portfolio.”
The company said that keeping its listing on the Cboe Canada exchange has become financially burdensome given the low trading volume of its shares. Filament will seek shareholder approval to delist at a special meeting on May 6.
“This financing, in conjunction with the planned delisting, will allow for the pursuit of certain near-term objectives,” Co-founder and CEO Benjamin Lightburn said. The company noted that “certain opportunities, including future potential listings on senior U.S. exchanges, are hindered by maintaining an active listing on Cboe Canada.”
Despite the delisting plans, Filament said it will continue as a reporting issuer, remaining subject to disclosure obligations under Canadian securities laws.
Filament Health focuses on developing naturally-derived psychedelic medicines through its proprietary drug development platform. The company claims to have “the first-ever natural psychedelic drug candidates” in its pipeline.
In its 2024 year-end results released earlier this week, the company posted a net loss of $4.97 million and cash reserves of just $391,237 as of Dec. 31, down from $1.83 million a year earlier. Annual revenue fell to $616,678 from $2.13 million in 2023.
Filament’s financials also included a going concern note from auditors, indicating “material uncertainties regarding the company’s ability to execute its business plan and continue in the normal course of operations” due to negative cash flow and an accumulated deficit of $36.12 million, Green Market Report reported.
Lightburn in its earnings release pointed to its lead program PEX010, which showed promise in recent clinical trials. According to the company, a Phase 2 clinical trial at Psychiatric Centre Copenhagen found that a single dose of PEX010 reduced heavy drinking days by more than 50% over a 12-week observation period in patients with severe alcohol use disorder.
The net proceeds from the financing will now provide “additional financial flexibility” for the company as it continues clinical development efforts. At the same time, there will be no transaction fees or closing costs associated with the private placement, with the entire C$900,000 going directly to the company.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.
Business
New York cannabis chief outlines plan for New York cannabis

Published
3 hours agoon
April 4, 2025
Felicia Reid took over as interim executive director of the New York Office of Cannabis Management during a tumultuous period. The state Office of General Services had just released a scathing audit and Gov. Kathy Hochul lambasted the state’s recreational marijuana market as a “disaster.”
Now, a year later and just past the fourth anniversary of the 2021 state law which legalized adult-use cannabis, Reid believes things in the New York cannabis market have turned a corner for the better.
In an interview this week with Green Market Report, Reid shared an optimistic view of how the market continues to evolve combined with real-world clarity on the dangers posed by the still-thriving illicit marijuana trade.
This interview has been edited for length and clarity.

You came on during a tumultuous time. How do you feel like the industry is doing currently almost a year later?
Reid: It has been a amazing whirlwind of almost a year. I really can’t believe all that’s happened, especially in the environment that I came in. There was criticisms of the agency’s practice and its process. There was the Office of General Services look into the agency’s operations.
I needed to engage very particularly with not just the folks in the OCM, but really with our stakeholders. I’m really conscious that this plant is so personal to so many people. I hear it all the time. It’s even personal in my own life.
I’m not somebody who’s here to say I have a title and then not do the work that comes along with it. For me, it was really showing both internally and externally that I wanted to show up to support that work. I wanted to make the connections that were necessary for this agency to survive, because it was going in a path where things were very much all over the place.
Several hundred CAURD licensees have had serious trouble getting open. One of the most common that I’ve heard is a lack of access to capital, and the CAURD permits are set to start expiring in June. What are your thoughts?
Reid: You’re a 100% right. The issue there is – and in this business writ large – is access to capital. There are a lot of folks who see dollar signs galore in this industry and want a piece of that, particularly because they have been specifically harmed by the way the state addressed cannabis. Folks have business acumen, but the structures around financing just aren’t there to support them.
One of the things that I’m really excited about with our CAURD program is we just opened up our CAURD grant, which allows for any CAURD licensee to apply for up to $30,000 in grant funding to be able to pay for any operating expense. Send us your receipts, send us your business expenses. If we can do something to help support that, then you’re eligible for these grant monies.
That’s a starting point.
I wish federal views on cannabis would change. But I think we’re not going to get help from the federal level. We as a state have to be very intentional around creating resources programming, and we have done some of that with our Cannabis Hub Incubator Program Academy that works to support our licensees in navigating some of the red tape and the bureaucracy.
We as an agency have to create some of those resources and support structures and some of those financial navigation abilities, but it’s really everyone working toward the same end, which is the survival of New York cannabis. We have as an agency have a lot of work to do to address the stigma, which is also where some of our licensees are getting hung up.
Are you going to support another extension for the CAURDs?
Reid: We just did a first extension of the licensees (in November), and I think we’ll have to see what’s happening on the ground relative to a question around a second. I don’t want to commit to anything, because I am very much an evidence-based person. And I always want to see where things are at as we’re contemplating a policy change or extending or granting an ability for our licensees.
One of the other big policy moving targets has been the number of business licenses that are going to be issued by the state. Has the OCM gotten any closer to figuring out where the cutoff might be?
Reid: That direction has to come from the Cannabis Control Board. At a board meeting last year, they did a resolution around licensing targets and coming to some conclusion around that – and the best that we can do as an agency is to provide the board with as much information about what the market looks like and what we’re seeing.
The OCM did make a recommendation to the board in December around licensing in terms of what we were seeing. A lot of our cultivators, a lot of our processor distributors, all of them got licensed last year, which means that they haven’t totally operationalized until this year. So we’re not going to know until October this year what the impact of that is.
But one of the things that we’re also very mindful of is we don’t want to oversaturate and we don’t want to devalue having a license, which is what we’ve seen in other jurisdictions on the supply side. The best that we can do is pay attention to what we’re seeing on the ground, but also what’s happened in other jurisdictions.
As to the retail side, we made a recommendation to get upwards of between 1,600 and 2,000 on the retail side, and we’re only at 335 open for business right now. So we have a lot of growth left on the retail side of things. But again, we’re waiting and relying on the board to make something conclusive and concrete for the industry about what it can expect based on OCM’s recommendations.
Do you have any guess as to what the outcome is going to be for the thousands of license applicants from the December queue that are still waiting and holding on to hope that they may be eventually going to get a permit?
Reid: There are a lot of people with hopes in this industry, and at a certain point, hopes meet the cold reality of both market forces but also other prerogatives. The thing I always say to businesses is, don’t plan for the industry that exists now. Pay attention to what’s happening in other jurisdictions. Pay attention to what may be the long-term outcome of a policy or a practice, because that’s the future that your business is going to have to orient toward.
When it comes to some of the most successful folks in this industry, (they’re) folks who are constantly doing their homework around what will work and what will not.
We’ve started to walk into the December queue on the retail side specifically, because if we’re not done with the November queue, we’re about to be done.
What are you hearing and seeing as far as the unlicensed market, not just in New York City, but across the state? Is that still a serious problem?
Reid: It is a problem. I’m not going to sugarcoat that. That requires us as an agency to be just as dogged and to get ahead of the ways in which we see things moving. And I will say on the unlicensed side, we’ve seen all sorts of machinations. It’s not just the brick and mortar; it’s folks taking advantage of the mail.
I’m also glad that we created our Trade Practice Unit to be able to go after folks who are licensees who are doing these types of machinations. That work has not stopped. Over the last couple of weeks, our OCM investigations team has been out training other jurisdictions on their enforcement practices.
If we were a small state, having our arms around this issue would a lot easier. But we’re a large state with many different regional attitudes and environments. And so with that, we also want to make sure that law enforcement partners at the local level are also standing up their own enforcement actions.
One CAURD licensee I spoke to recently told me he’s homeless because he’s put literally everything he’s had into trying to open a dispensary in the Hamptons, but can’t get it done. What would you want to say to that demographic of cannabis license applicant?
Reid: The industry that I came into in June last year is not the industry in March of 2025. Things have changed so much, and I certainly understand from an applicant’s perspective, feeling like it is starting to get away.
There is this sort of time pressure to be able to participate in this industry, and participating in the industry, of course, isn’t a guarantee of success. I’m trying to ensure that we as an agency aren’t creating policy missteps or mistakes or overpromising and underdelivering, because I think that elevates hopes and expectations in a way that’s unreasonable. I always want to make sure that the agency is communicating where it’s at, what it’s doing, what it’s looking at.
The best I can do is put that information out there.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.
Business
Jones Soda keys in on three-prong strategy, with cannabis playing a critical role

Published
11 hours agoon
April 4, 2025
Jones Soda Co. (OTCQB: JSDA), a Seattle-based craft soda maker known for its quirky flavors and customer-submitted label photos, has been aggressively expanding past its traditional soda roots since entering the cannabis market in 2021 with its Mary Jones brand. And after a challenging 2024, alternative adult beverages will be front and center of the company’s go-forward strategy.
“While Jones Soda started the year on a strong note, several operational challenges along with poor financial discipline in the back half of the year hindered our growth and tested the company’s resilience,” newly appointed CEO Scott Harvey said during the company’s fourth-quarter earnings call.
The company reported a 15% increase in revenue to $19.1 million for 2024, but its net loss widened from $4.9 million in 2023 to $9.9 million in 2024, in part due to the financial pressures of competing in multiple beverage categories simultaneously.
Jones’ hemp-derived HD9 products, which launched in January 2024, raked in $1.7 million in revenue during their first year – a bright spot for the company as it navigates a market more saturated by the day. Its cannabis THC segment also saw modest growth, generating $1.3 million in revenue versus around $1.2 million in 2023.
The overall cannabis beverage sector – particularly with hemp – has seen a boon since states began legalizing recreational marijuana use, with major beverage companies and startups alike introducing THC and CBD-infused drinks. Established players in recent years, such as Canopy Growth Corp. (backed by Constellation Brands) and Hexo (which partnered with Molson Coors), creating challenges for smaller operators like Jones.
Harvey acknowledged the rapidly evolving regulatory environment surrounding hemp-derived products, which has created both opportunities and uncertainty for the company.
“We’re closely monitoring the landscape of the HD9 category. We understand the regulating shifts being considered by the states’ attorneys general and congressional bodies,” Harvey said, noting that the company is “proactively engaging with regulatory bodies” to ensure compliance.
Harvey cited trend data suggesting that “over the next three years, $1 every $5 spent within the beverage category will be spent on alternative products like Mary Jones, serving as substitutes for traditional adult beverages like beer and wine.”
Historically, the company’s push into cannabis and hemp beverages represents a strategic pivot for a brand that has struggled to achieve consistent profitability since its founding in 1995. After reaching peak popularity in the early 2000s, Jones faced intense competition from both major soda manufacturers and craft beverage startups, leading to years of financial struggles.
CFO Brian Meadows – who previously held executive positions at Black Rifle Coffee Company, Nathan’s Famous and Dunn Brothers Coffee – emphasized the need for financial discipline going forward, noting that the company has implemented new processes for contract review and approval.
“Jones does have the right products now to focus on. We have our contract review processes buttoned down. Marketing spend is only approved with clear ROI,” Meadows said. “And Scott (Harvey) and I are very focused on working with the team on improved supply chain management processes and inventory management.”
Jones even secured a new $5 million revolving credit facility in February as a way to address liquidity concerns in such a capital-intensive industry. The facility provides a “larger and more flexible credit line” that allows the company to borrow against inventory, accounts receivable and customer purchase orders.
Jones is pursuing a three-pronged strategy focusing on core soda, modern soda and adult beverages – an approach that Harvey said positions the company to compete effectively in multiple growing segments rather than relying solely on its legacy soda business or emerging cannabis offerings. The strategy follows a vision established by the company’s chairman, Paul Norman, who discussed corrective actions during the previous quarterly update.
The company’s expanded distribution network now includes 81 partners across 37 states, securing placement in major retailers including Kroger, Albertson-Safeway and Meijer. Meanwhile, its Mary Jones HD9 line has signed 32 distribution partners since launch, including four in the first quarter of 2025 to expand into two new states.

Author: mscannabiz.com
MScannaBIZ for all you Mississippi Cannabis News and Information.

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